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ProteomicsThe Rac-GEF Tiam1 controls integrin-dependent neutrophil responses
Rac GTPases are required for neutrophil adhesion and migration, and for the neutrophil effector responses that kill pathogens. These Rac-dependent functions are impaired when neutrophils lack the activators of Rac, Rac-GEFs from the Prex, Vav and Dock families. In this study, we demonstrate that Tia...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD046791 | Pride
Tiam1 Dock2 Vav Neutrophils Rac Prex1 Rac-gef Small gtpase 
ProteomicsA Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia...
3xFLAG-IPs from HEK293T cell lysates expressing 3xFLAG-bait or 3xFLAG-control. Trypsin Digestion
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-04-09 | MSV000079100 | MassIVE
GenomicsRAC-GEF function as a critical factor in intestinal tumourigenesis
RAC-GEF function as a critical factor in intestinal tumourigenesis
PRJNA445428 | ENA
TranscriptomicsCharacterization of a P-REX1 gene signature in breast cancer cells
The Rac nucleotide Exchange Factor (Rac-GEF) P-Rex1 is highly expressed in breast cancer, specifically in the luminal subtype, and is an essential mediator of actin cytoskeleton reorganization and cell migratory responses induced by ErbB and other tyrosine-kinase receptors. Heregulin, a growth facto...
ORGANISM(S): Homo sapiens 
2016-09-07 | E-GEOD-77974 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles in naïve WT and Asc-null bone marrow derived dendritic cells
The adaptor protein ASC contributes to innate immunity through the assembly of caspase-1-activating inflammasome complexes. We demonstrate that ASC plays an inflammasome-independent cell-intrinsic role in adaptive immune cells. Asc-/- mice displayed defective antigen presentation by dendritic cells ...
ORGANISM(S): Mus musculus 
2012-07-08 | E-GEOD-30769 | biostudies-arrayexpress
UnknownA RAC-GEF network critical for early intestinal tumourigenesis.
Not available
S-EPMC7782582 | biostudies-literature
UnknownRac GEF Dock4 interacts with cortactin to regulate dendritic spine formation.
Not available
S-EPMC3655820 | biostudies-literature
ProteomicsRheb and TRF1 PhastID mass spectrometric data
Rheb is a small G protein that functions as the direct activator of the mechanistic target of rapamycin complex 1 (mTORC1) to coordinate signaling cascades in response to nutrients and growth factors. Despite extensive studies, the guanine nucleotide exchange factor (GEF) that directly activates Rhe...
ORGANISM(S): Homo Sapiens 
PXD037078 |
UnknownPhosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis.
Not available
S-EPMC5739283 | biostudies-literature
UnknownP-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity.
Not available
S-EPMC12569377 | biostudies-literature
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