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ProteomicsAlexander disease mutations differentially sensitize GFAP to oxidative damage and network disruption
The type III intermediate filament protein GFAP plays key roles in astrocyte and brain homeostasis. Mutations in GFAP can result in Alexander’s disease (AxD), a severe neurodegenerative disease. Studies in AxD models indicate that oxidative stress may be an important pathogenic factor. Expression of...
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD069155 | Pride
Human Brain Disulfide Oxidation Gfap 
ProteomicsAn Immunological Synapse Formation Between T Regulatory Cells and Cancer-Associated Fibroblasts Promotes Tumour Development
The cells were lysed in a buffer consisting of 4% SDS, 0.1 M DTT, 100 mM Tris/HCl; pH 7.6 and heated for 5 minutes at 99℃. The protein extracts were processed according to theSp3 protocol. The reduced cysteine residues were alkylated in 200 mM iodoacetamide (Acros Organics). 20 μg of beads (1:1 mixt...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-08 | PXD047024 | Pride
Autophagy Cancer-associated fibroblasts Immune synapse Immunity T regulatory cells Anti-tumour immunity Antigen presentation 
UnknownBRCA1/2 Mutations and Bevacizumab in the Neoadjuvant Treatment of Breast Cancer: Response and Prognosis Results in Patients With Triple-Negative Breast Cancer From the GeparQuinto Study.
Not available
S-EPMC6067803 | biostudies-literature
ProteomicsAn SRRM3 regulated neural alternative splicing program is subverted to promote tumour progression in pancreatic neuroendocrine cells.
Pancreatic neuroendocrine tumours (PanNETs) are a heterogeneous group of neoplasms arising in pancreatic islets and altering the hormone secreting function of neuroendocrine cells. Genome wide approaches have revealed the genomic landscape of PanNETs but have not explained their problematic hormone ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-08 | PXD065389 | Pride
Alternative splicing Microexons Pancreatic neuroendocrine tumours Insulin secretion Srrm3 
UnknownInherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.
Not available
S-EPMC4302212 | biostudies-literature
ProteomicsAcellular ECM Proteomics: Versican expression from lung fibroblasts is an autologous fibrotic brake
The activation and accumulation of lung fibroblasts, leading to excessive extracellular matrix (ECM) deposition, is a pathogenic hallmark of Idiopathic Pulmonary Fibrosis (IPF), a lethal and currently incurable disease. The collagen-rich fibrotic ECM perpetuates fibroblast activation and accumulatio...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD063546 | Pride
Aecm Pulmonary fibrosis  extracellular matrix (ecm)  lung fibroblasts  podosomes  ecm invasion  versican (vcan)  hyaluronan (ha)  collagens 
UnknownA small, lightweight multipollutant sensor system for ground-mobile and aerial emission sampling from open area sources.
Not available
S-EPMC6223182 | biostudies-literature
ProteomicsChronic optogenetic activation of hippocampal pyramidal neurons replicates the proteome footprint of Alzheimer’s disease-like pathology
Neuronal overexcitability can disrupt synapse formation and strength and elicit synaptic changes which in turn give rise to neuronal hyperactivity, and eventually overall abnormal neural circuit processing. Such network disruption impairs neuronal function and survival, resulting in the onset of neu...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-01 | PXD044437 | Pride
Neuronal hyperactivity  hippocampus  optogenetics  stable step function opsin (ssfo)  proteomics  alzheimer’s disease  neurodegeneration 
ProteomicsUrolithin A rewires inter-organellar communication via calcium signaling to promote mitophagy and longevity
Mitochondrial damage and mitophagy deregulation are hallmark features of aging and age-related pathologies. Urolithin A (UA), a potent mitophagy inducer, is known to confer neuroprotection, maintain muscle integrity, and extend healthspan and lifespan across diverse species. However, the molecular m...
ORGANISM(S): Caenorhabditis elegans 
2025-10-15 | PXD056571 | Pride
Itr-1/insp3r Mitophagy Lysosome Tmco-1/tmco Mcu-1/mcu1 Geroprotection Calcium Mitochondria Emc-3/emc3 Aging Urolithin a Er 
UnknownToxicity Assessment of a Phase III Study Evaluating FEC-Doc and FEC-Doc Combined with Gemcitabine as an Adjuvant Treatment for High-Risk Early Breast Cancer: the SUCCESS-A Trial.
Not available
S-EPMC4873296 | biostudies-literature
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