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TranscriptomicsAccumulation of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication
Checkpoints are cellular surveillance and signaling pathways that regulate responses to DNA damage and perturbations of DNA replication. Here we show that high levels of sumoylated Rad52 are present in the mec1 sml1 and rad53 sml1 checkpoint mutants exposed to DNA damaging agents such as methyl meth...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-18 | E-GEOD-14761 | biostudies-arrayexpress
ProteomicsRAD52 resolves transcription-replication conflicts to mitigate R-loop induced genome instability
Collisions of the transcription and replication machineries on the same DNA strand can pose a significant threat to genomic stability. These collisions occur in part due to the formation of RNA-DNA hybrids termed R-loops, in which a newly transcribed RNA molecule hybridizes with the DNA template str...
ORGANISM(S): Homo sapiens (Human) 
2024-08-25 | PXD054611 | Pride
Rad52 Ip-mass spec Human cells 
ProteomicsA Split-SUMO-ID proteomics approach to identify the Rad52 and SUMO-dependent interactome of Schizosaccharomyces pombe
A PTM known as sumoylation, manifested by an attachment of a SUMO molecule (small ubiquition-like modifier) to target proteins, may lead to changes in the tagged protein’s function, localization or stability. This PTM is present in all eukaryotes. In fission yeast, Rad52 is a DNA repair mediator pro...
ORGANISM(S): Schizosaccharomyces pombe 
2025-10-31 | PXD055556 | Pride
ProteomicsMechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination
Homologous recombination (HR) repairs double-stranded DNA breaks (DSBs). The DSBs are resected to yield single-stranded DNA (ssDNA) that are coated by Replication Protein A (RPA). Rad51 is a recombinase and catalyzes strand invasion and the search for homology. However, it binds to ssDNA with lower ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2025-07-28 | PXD065573 | Pride
Cross-linking Lc-msms 
GenomicsChIP-on-chip Rad52 in early S phase (time 60min)
ChIP-on-chip Rad52 in early S phase (time 60min)
PRJNA451509 | ENA
GenomicsAccumulation of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication
Checkpoints are cellular surveillance and signaling pathways that regulate responses to DNA damage and perturbations of DNA replication. Here we show that high levels of sumoylated Rad52 are present in the mec1 sml1 and rad53 sml1 checkpoint mutants exposed to DNA damaging agents such as methyl meth...
ORGANISM(S): Saccharomyces cerevisiae 
2009-05-26 | GSE14761 | GEO
GenomicsChIP-on-chip Rad52 in unperturbed S phase (no HU treatment)
ChIP-on-chip Rad52 in unperturbed S phase (no HU treatment)
PRJNA418980 | ENA
GenomicsGenome-wide Rad52 chromatin association in S. pombe following depletion of Swi1
Genome-wide Rad52 chromatin association in S. pombe following depletion of Swi1
PRJNA1507819 | ENA
GenomicsPolySUMOylation of PCNA and Rad52 restricts centromeric recombination in fission yeast
PolySUMOylation of PCNA and Rad52 restricts centromeric recombination in fission yeast
PRJNA1159126 | ENA
ProteomicsRegulation of Rad52-dependent replication fork recovery through serine ADP-ribosylation of PolD3
Although Poly(ADP-ribose)-polymerases (PARPs) are key regulators of genome stability, how site-specific ADP-ribosylation regulates DNA repair is unclear. Here, we describe a novel role for PARP1 and PARP2 in regulating Rad52-dependent replication fork repair to maintain cell viability when HR is dys...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035661 | Pride
Proteomics Dna repair Adpr Parps Lumos Adp-ribosyltransferases Adp-ribosylation Af1521 Dna replication 
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