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ProteomicsMass spectrometric profiling of HLA-B44 peptidomes provides evidence for tapasin-mediated tryptophan editing
The extreme polymorphisms of human leukocyte antigen (HLA) class I proteins result in structural variations in their peptide binding sites to achieve diversity in antigen presentation. External factors could independently constrict or alter HLA class I peptide repertoires. Such effects of the assemb...
ORGANISM(S): Homo sapiens (Human) 
2024-07-15 | PXD046825 | Pride
Hla-b*44:02 Hla-b*44:05 Tapasin Peptide binding affinity Tryptophan Peptide loading complex Hla class i Immunopeptidome Half-life Mhc class i 
ProteomicsCalreticulin enhances the secretory trafficking of a polymerogenic alpha1-antitrypsin
α-1-antitrypsin (AAT) regulates protease activity in the lungs and liver. The presence of one or more copies of a mutant Z allele (AAT (E342K), called ATZ), results in low serum levels of ATZ along with intracellular inclusions of polymeric forms, causing lung emphysema and liver cirrhosis. Our expe...
ORGANISM(S): Homo sapiens (Human) 
2020-09-24 | PXD020562 | Pride
Calreticulin Alpha1-antitrypsin Copii Secretory trafficking Calnexin 
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