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UnknownSelective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.
Not available
S-EPMC4207991 | biostudies-literature
ProteomicsProteome profile of Traf6-OE OT-I T cells
Proteome profile of Traf6-OE OT-I T cells and EV OT-I cells after viral transfection
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD039327 | Pride
Mouse Lc-ms Traf6-oe ot-i t cells 
GenomicsGenome wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer
Background: 5-hydroxymethylcytosine (5-hmC) is a recently discovered epigenetic modification that is altered in cancers. Genome wide assays for 5-hmC determination are needed as many of the techniques commonly used to assay 5-methylcytosine (5-mC), including conventional methyl-sensitive restriction...
ORGANISM(S): Homo sapiens 
2013-07-30 | E-GEOD-42723 | biostudies-arrayexpress
UnknownImplication of myddosome complex genetic variants in outcome severity of COVID-19 patients.
Not available
S-EPMC10273757 | biostudies-literature
ProteomicsIdentification of MELK-interacting proteins in HEK293T cells using IP-MS
To investigate the mechanism by which Maternal Embryonic Leucine Zipper Kinase (MELK) regulates the actin cytoskeleton and affects coronavirus infections, we performed an Immunoprecipitation-Mass Spectrometry (IP-MS) assay. The goal was to identify specific actin-binding proteins that interact with ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD057095 | Pride
ProteomicsIdentification of MELK-mediated Cofilin-1 T70 phosphorylation by IP-LC-MS/MS analysis
To investigate whether MELK phosphorylates Cofilin-1 at residue Threonine 70 (T70), we performed a phosphoproteomic validation using immunoprecipitation coupled with mass spectrometry (IP-LC-MS/MS). HEK293T cells were divided into three experimental groups: (1) MOCK control (Empty Vector), (2) MELK ...
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD074164 | Pride
Cofilin-1 Melk Immunoprecipitation Affinity purification-ms Otssp167 Hek293t T70 phosphorylation Lc-ms/ms 
Proteomicsglobal proteomics profiling of Huh7 cells infected with human coronaviruses (SARS-CoV-2, HCoV-229E, and HCoV-OC43)
To explore host factors and pathways modulated by coronavirus infections, we performed global quantitative proteomics profiling. Huh7 cells were infected with SARS-CoV-2 (MOI=1.0), HCoV-229E (MOI=0.1), or HCoV-OC43 (MOI=1.0) for 24 hours, compared with MOCK infection. Protein samples were digested a...
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD057194 | Pride
Proteomicsglobal phosphoproteomics during human coronavirus infections
For phosphoproteomics analysis, cells were harvested at 24 hours post infections. All samples were analyzed using mass spectrometry with a data-independent analysis (DIA) approach to measure changes in both protein abundancelevel upon infections.
ORGANISM(S): Homo sapiens (Human) 
2026-04-01 | PXD057224 | Pride
Phosphoproteomics Human coronavirus 
UnknownEffect of antibiotic-induced intestinal dysbacteriosis on bronchopulmonary dysplasia and related mechanisms.
Not available
S-EPMC8054697 | biostudies-literature
TranscriptomicsHigh resolution methylome analysis reveals widespread functional hypomethylation during adult human erythropoiesis
Differentiation of hematopoietic stem cells to red cells requires coordinated expression of numerous erythroid genes. To understand the regulatory mechanisms governing lineage commitment we conducted a high resolution methylomic and transcriptomic analysis of six major stages of human erythroid diff...
ORGANISM(S): Homo sapiens 
2013-02-05 | E-GEOD-44054 | biostudies-arrayexpress
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