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ProteomicsA chemical strategy for protease substrate profiling
Here, we introduce a simple method, termed CHOPS, for the discovery of protease substrates. CHOPS exploits a 2-pyridinecarboxaldehyde (2PCA)-biotin probe, which selectively biotinylates protein N-termini except those with proline in the second position. CHOPS can, in theory, discover substrates for...
ORGANISM(S): Homo sapiens (Human) 
2019-04-23 | PXD013019 | Pride
Chops Silac N-terminomics 
TranscriptomicsCryptic Transcription in a set2∆ in Saccharomyces cerevisiae
In cells lacking the histone methyltransferase Set2, initiation of RNA polymerase II transcription occurs inappropriately within the protein-coding regions of genes, rather than being restricted to the proximal promoter. Here, we mapped the transcripts produced in an S. cerevisiae strain lacking Set...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-17 | E-GEOD-13310 | biostudies-arrayexpress
UnknownMolecular Modeling and Functional Analysis of Exome Sequencing-Derived Variants of Unknown Significance Identify a Novel, Constitutively Active FGFR2 Mutant in Cholangiocarcinoma.
Not available
S-EPMC6369924 | biostudies-literature
ProteomicsGlobal proteomics of HEK293T cells treated with Val-boroPro for 48h
Global proteomics of HEK293T cells treated with Val-boroPro for 48h
ORGANISM(S): Homo sapiens (Human) 
2020-10-14 | PXD015978 | Pride
Val-boropro Tmtsixplex 
UnknownA novel case of glial transdifferentiation in renal medullary carcinoma brain metastasis.
Not available
S-EPMC11748356 | biostudies-literature
ProteomicsDPP9 activity and not protein binding inhibits the CARD8 inflammasome
Inflammasomes are multiprotein complexes formed in response to pathogens. NLRP1 and CARD8 are related proteins that form inflammasomes, but the pathogen-associated signal(s) and the molecular mechanisms controlling their activation have not been established. Inhibitors of the serine dipeptidyl pept...
ORGANISM(S): Homo sapiens (Human) 
2019-10-23 | PXD015047 | Pride
Val-boropro Card8 Dpp9 
UnknownMultiscale photoacoustic tomography of neural activities with GCaMP calcium indicators.
Not available
S-EPMC9463545 | biostudies-literature
GenomicsMulti-Site Collaborative Study for Genotype-Phenotype Associations in Alzheimer's disease and Longitudinal follow-up of Genotype-Phenotype Associations in Alzheimer's disease and Neuroimaging component of Genotype-Phenotype Associations in Alzheimer's disease

GenADA is a multi-site collaborative study, involving GlaxoSmithKline Inc and nine medical centres in Canada, to develop a dataset containing 1000 Alzheimer's disease patients and 1000 ethnically-matched controls in order to associate DNA sequence (allelic) variations in candidate genes w...

phs000219.v1.p1 | EGA
UnknownPredominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts.
Not available
S-EPMC4973113 | biostudies-literature
UnknownDouble crossed? Structural and computational studies of an unusually crosslinked haem in <i>Methylococcus capsulatus</i> cytochrome P460.
Not available
S-EPMC12352625 | biostudies-literature
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