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MetabolomicsMesenchymal stromal cells secretome restores bioenergetic and redox homeostasis in human proximal tubule cells after ischemic injury

BACKGROUND: Ischemia/reperfusion injury (IRI) is the leading cause of acute kidney injury (AKI). The current standard of care focuses on supporting kidney function, stating the need for more efficient and targeted therapies to enhance repair. Mesenchymal Stromal Cells (MSCs) and ...

2023-10-16 | MTBLS6279 | MetaboLights
ProteomicsFly Stress - Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster
Altering the redox state of cysteine residues on protein surfaces is an important response to environmental challenges. While ageing and fasting alter many redox processes, the role of cysteine residues is uncertain. To address this we used a redox proteomic technique, Oxidative Isotope Coded Affini...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-10-24 | PXD002195 | Pride
Drosophila Starvation Ros Aging 
TranscriptomicsTranscription profiling of Arabidopsis leaves reponse to DTT to examine the effect of redox on gene expression
In this study, we used GC-MS analysis in combination with flux analysis and the Affymetrix ATH1 GeneChip to survey the metabolome and transcriptome of Arabidopsis leaves in response to manipulation of the thiol-disulfide status. Feeding low concentrations of the sulfhydryl reagent dithiothreitol (DT...
ORGANISM(S): Arabidopsis thaliana 
2008-06-12 | E-GEOD-4021 | biostudies-arrayexpress
ProteomicsRedox-proteomic analysis of pancreatic β-cells upon glucose stimulation
Redox signaling mediated by reversible oxidative cysteine thiol modifications is crucial for driving cellular adaptation to dynamic environmental changes, maintaining homeostasis, and ensuring proper function. This is particularly critical in pancreatic β-cells, which are highly metabolically active...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2024-09-30 | PXD052765 | Pride
Iodotmt Redox proteomics 
ProteomicsTemporal profiling of redox-dependent heterogeneity in single cells
Cellular redox status affects diverse cellular functions, including proliferation, protein homeostasis, and aging. Thus, individual differences in redox status can give rise to distinct sub-populations even among cells with identical genetic backgrounds. Here, we have created a novel methodology to ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-06-18 | PXD009443 | Pride
Yeast Redox 
ProteomicsQuantification of cellular protein and redox imbalance using SILAC-iodoTMT methodology
A new analytical method capable of simultaneously assessing cellular protein expression and cysteine oxidation would provide a valuable tool for the field of cysteine-targeted biology. Here, we show a workflow based on protein quantification using metabolic labeling and determination of cysteine oxi...
ORGANISM(S): Homo sapiens (Human) 
2026-09-03 | PXD012504 | Pride
Cysteine Liquid chromatography/mass spectrometry Silac-iodotmt labeling Peroxiredoxin Proteome Redoxome 
ProteomicsDysregulated cellular redox status during hyperammonemia causes mitochondrial dysfunction by inhibiting sirtuin mediated deacetylation
Perturbed metabolism of ammonia, an endogenous cytotoxic molecule, causes mitochondrial dysfunction with decreased nicotinamide adenine dinucleotide (NAD+) in skeletal muscle. Consistent with our previous report of enrichment of NAD metabolism and sirtuin pathways during hyperammonemia, NAD+-depende...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD033430 | Pride
Multiomic Mitochondria Redox ratio Hyperacetylation Sirtuin 
UnknownNitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging.
Not available
S-EPMC8792502 | biostudies-literature
GenomicsChloroplast redox status modulates genome-wide plant responses during drought
Chloroplast redox status modulates genome-wide plant responses during drought
PRJNA628931 | ENA
GenomicsVanin-1 deficiency enhances host tolerance to influenza infection by modulating cellular redox status
Vanin-1 deficiency enhances host tolerance to influenza infection by modulating cellular redox status
PRJNA1269591 | ENA
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