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ProteomicsMicrofluidic chip-enabled proteome profiling of bacterial infection of macrophages reveals new pathogenic regulators of immune evasion.
Microfluidic chip enabled cell sorting of non-phagocytosed K. pneumoniae cells from BALB/c macrophages during co-culture. These cell populations were analyzed to determine differences in phagocytosed K. pneumoniae versus non-phagocytosed at the protein level. This resulted in the identification of s...
ORGANISM(S): Klebsiella pneumoniae 
2026-03-24 | PXD051800 | Pride
Pneumoniae 240 Exploris Proteome Klebsiella Iron. 
ProteomicsPhosphoproteome modulation by zinc and iron in Klebsiella pneumoniae reveals new virulence mechanisms and antibacterial targets
Klebsiella pneumoniae is a Gram-negative bacterium causing 10-20% mortality in immunocompromised individuals and is known to rapidly develop resistance towards existing antibiotics. This underscores a need for novel antimicrobials or strategies for resensitization. Bacterial adaptation to iron and z...
ORGANISM(S): Klebsiella pneumoniae subsp. pneumoniae 
2026-04-15 | PXD072239 | Pride
Pneumoniae Exploris Phosphorylation Bacteria Phosphoproteomics Iron Klebsiella Zinc 
ProteomicsLon Protease-Mediated Secretome Profiling in Klebsiella pneumoniae
Lon protease is a global regulator in bacteria, affecting biofilm formation, antibiotic resistance, toxin-antitoxin complexes and proteolysis of damaged proteins. This study uses bottom-up proteomics to identify Klebsiella pneumoniae proteins with altered secretion patterns in the absence of lon and...
ORGANISM(S): Klebsiella pneumoniae 
2024-11-01 | PXD057415 | Pride
Klebsiella Pneumoniae Bacteria Iron Secretome 
ProteomicsProfiling of the Cellular Proteome and Phosphoproteome of Klebsiella pneumoniae under Zinc Limited and Zinc Replete Conditions
Klebsiella pneumoniae is a bacterial pathogen that causes nosocomial infection in humans and is acquiring antibiotic resistance at an alarming rate. This study investigates the effect of zinc limitation on the phosphoproteome of K. pneumoniae using quantitative mass spectrometry to provide insight i...
ORGANISM(S): Klebsiella pneumoniae subsp. pneumoniae 
2023-03-23 | PXD041015 | Pride
Klebsiella Lc-msms Phosphoproteome Pneumonia 
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