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ProteomicsThe ataxia-telangiectasia disease protein ATM controls vesicular protein secretion via CHGA and microtubule dynamics via CRMP5
Ataxia telangiectasia mutated (ATM) is a protein that belongs to the family of phosphatidylinositol 3-kinase (PI3K)-like serine/threonine kinases. Initially identified as a nuclear protein essential for the DNA damage response (DDR) in mitotic cells, it serves as repair coordinator for DNA double-st...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-09-29 | PXD058394 | Pride
Taxol Sodium arsenite Coimmunoprecipitation Differential ultracentrifugation Label-free mass spectrometry Chloroquine Immobilized metal affinity chromatography Phosphoscan 
UnknownIdentification of absorbed compounds of Xiao Yao San Jia Wei and pharmacokinetic study in depressed rats by force swimming stress.
Not available
S-EPMC8981079 | biostudies-literature
ProteomicsS6K1 Phosphoproteome in Tsc1-null mouse kidney iMCD3 cells
Loss of Tsc1 in the kidneys gives rise to rapid polycystogenesis and kidney failure due to the hyperactivation of mTOR complex I (mTORC1). One of the major downstream targets of mTORC1 is S6K1, which is responsible for driving many of the effector functions of mTOR. Strikingly, the loss of S6k1 in t...
ORGANISM(S): Mus musculus (Mouse) 
2020-08-11 | PXD014832 | Pride
S6k1 Tsc1 Kidney Phosphoproteome Mtor 
ProteomicsDevelopment and characterization of selective FAK inhibitors and PROTACs with in vivo activity
Focal adhesion kinase (FAK) is an attractive drug target due to its overexpression in cancer. FAK functions as a non-receptor tyrosine kinase and scaffolding protein, coordinating several downstream signaling effectors and cellular processes. While drug discovery efforts have largely focused on targ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD039828 | Pride
Fak Inhibitor Protac Degrader 
UnknownHost-inducible immunogenic sphingomyelinase-like protein, Lk73.5, of Leptospira interrogans.
Not available
S-EPMC321616 | biostudies-literature
ProteomicsMass spectrometry (MS) datasets of QKI5 co-immunoprecipitation samples in THP-1 cells
We performed QKI5 co-immunoprecipitation followed by MS analysis to identify QKI5-interacting proteins in THP-1 cells.
ORGANISM(S): Homo sapiens (Human) 
2021-09-27 | PXD028743 | Pride
Qki5 co-immunoprecipitation  mass spectrometry  thp-1 cells 
ProteomicsA global screening identifies chromatin-enriched RNA-binding proteins and the transcriptional regulatory activity of QKI5 during monocytic differentiation [RBP screening THP-1 cells]
We process mass spectrome datasets of RNA binding proteins(RBPs) in soluble nuclear extract (SNE) and chromatin-pellet extract (CPE) from THP-1 cells.
ORGANISM(S): Homo sapiens (Human) 
2021-09-27 | PXD028787 | Pride
Nuclear rbp  thp-1 cells 
ProteomicsA global screening identifies chromatin-enriched RNA-binding proteins and the transcriptional regulatory activity of QKI5 during monocytic differentiation [RBP screening 293T cells]
We process mass spectrome datasets of RNA binding proteins(RBPs) in soluble nuclear extract (SNE) and chromatin-pellet extract (CPE) from 293T cells.
ORGANISM(S): Homo sapiens (Human) 
2021-09-27 | PXD028660 | Pride
Nuclear rbp  293t cells 
ProteomicsA global screening identifies chromatin-enriched RNA-binding proteins and the transcriptional regulatory activity of QKI5 during monocytic differentiation [RBP screening K562 cells]
We process mass spectrome datasets of RNA binding proteins(RBPs) in soluble nuclear extract (SNE) and chromatin-pellet extract (CPE) from K562 cells.
ORGANISM(S): Homo sapiens (Human) 
2021-09-27 | PXD028668 | Pride
Nuclear rbp  k562 cells 
UnknownOsteoarticular manifestations as initial symptoms of WD with novel compound heterozygote mutations in the ATP7B gene: a case report
Not available
S-EPMC8107867 | biostudies-literature
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