Sort   by:  
 Page size 
MetabolomicsA microfluidic chip recapitulating the human neurovascular unit with a functional blood-brain barrier for modeling gut-brain interactions

The blood-brain barrier (BBB) is essential for central nervous system homeostasis, but most current in vitro models lack structural and functional fidelity. We developed a physiologically relevant human neurovascular unit microfluidic chip (hNVU-on-a-chip) incorporating brain microvascular endoth...

2025-10-28 | MTBLS13230 | MetaboLights
MetabolomicsCalenduloside E produced by Bifidobacterium animalis B960 increases glibenclamide efficacy and alleviates drug-induced adverse effects via the IRS1/PI3K/AKT signaling pathway in a type 2 diabetes model Calenduloside E produced by Bifidobacterium animalis B960 increases glibenclamide efficacy and alleviates drug-induced adverse effects via the IRS1/PI3K/AKT signaling pathway in cell, organ-on-a-chip, and mouse models of type 2 diabetes.

Glibenclamide (GLIB), a type 2 diabetes therapy, has long-term safety concerns. Probiotic–drug coadministration, an emerging adjunctive approach for metabolic diseases, improves therapeutic outcomes and side effects. Here, Bifidobacterium animalis B960 was selected from 71 probiotic strains by HP...

2025-07-08 | MTBLS12697 | MetaboLights
ProteomicsChIP-MS reveals the local chromatin composition by label-free quantitative proteomics
Chromatin immunoprecipitation (ChIP) has been a cornerstone for epigenetic analyses over the last decades, but even coupled to sequencing approaches (ChIP-seq), it is ultimately limited to one protein at a time. In a complementary effort, we here combined ChIP with label-free quantitative (LFQ) mass...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-03-05 | PXD039627 | Pride
Chip-ms Dcas9 Telomeres Lfq Myb 
ProteomicsChIP-MS reveals the local chromatin composition by label-free quantitative proteomics
Chromatin immunoprecipitation (ChIP) has been a cornerstone for epigenetic analyses over the last decades, but even coupled to sequencing approaches (ChIP-seq), it is ultimately limited to one protein at a time. In a complementary effort, we here combined ChIP with label-free quantitative (LFQ) mass...
ORGANISM(S): Homo sapiens (Human) 
2024-03-05 | PXD039701 | Pride
Chip-ms Telomeres Lfq 
ProteomicsReverse Chromatin Immunoprecipitation (R-ChIP) to investigate the upstream regulators of a specific gene（CAT3 Promoter)-880
This project aim to explore the gene-centered approaches to investigate the interaction between DNA and protein
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-11-04 | PXD020755 | Pride
Reverse chip arabidopsis thaliana nucleus cat3 promoter 
ProteomicsReverse Chromatin Immunoprecipitation (R-ChIP) to investigate the upstream regulators of a specific gene（CAT3 Promoter）-722
This project aim to explore the gene-centered approaches to investigate the interaction between DNA and protein
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-11-04 | PXD020772 | Pride
Reverse chip arabidopsis thaliana nucleus cat3 promoter 
TranscriptomicsStress-dependent CHIP/Daxx interaction suppresses the p53 apoptotic program
Our previous studies have implicated CHIP as a co-chaperone/ubiquitin ligase, whose activities yield protection against stress-induced apoptotic events. In this report, we demonstrate a stress-dependent interaction between CHIP (carboxyl terminus of Hsp70-interacting protein) and Daxx, death domain-...
ORGANISM(S): Mus musculus 
2010-04-03 | E-GEOD-14339 | biostudies-arrayexpress
GenomicssiQ-ChIP: A reverse-engineered quantitative framework for ChIP-sequencing
siQ-ChIP: A reverse-engineered quantitative framework for ChIP-sequencing
PRJNA549445 | ENA
TranscriptomicsChromatin immunoprecipitation of Oct4 and nanog in mouse embryonic stem cells to enable comparison of regulatory networks obtained by ChIP-Chip and ChIP-PET
Genome-wide approaches have begun to elucidate the transcriptional and epigenetic regulatory networks responsible for pluripotency in embryonic stem (ES) cells. Chromatin Immunoprecipitation (ChIP) followed either by hybridization to a microarray platform (ChIP-chip), or by DNA sequencing (ChIP-PET...
ORGANISM(S): Mus Musculus 
2008-11-04 | E-TABM-410 | biostudies-arrayexpress
TranscriptomicsAnalysis of on-chip hybridization kinetics for optimization of gene expression experiments.
DNA microarray technology is a powerful tool for getting the overview of gene expression in biological samples. Although the successful application of microarray-based expression analysis was demonstrated in a number of applications, the main problem with this approach is the fact that expression le...
ORGANISM(S): Mus musculus 
2007-09-29 | E-GEOD-7574 | biostudies-arrayexpress
Sort   by:  
 Page size