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TranscriptomicsTranscription profiling of mouse fibroblasts to examine the cellular transformation induced by Rho subfamily GTPases
We have used microarray technology to identify the transcriptional targets of Rho subfamily GTPases. This analysis indicated that murine fibroblasts transformed by these proteins show similar transcriptomal profiles. Functional annotation of the regulated genes indicate that Rho subfamily GTPases ...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5913 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primary keratinocytes expressing Rho/CRIK to study the impact of Rho signaling pathway on gene expression.
Rho GTPases integrate control of cell structure and adhesion with downstream signaling events. In keratinocytes, RhoA is activated at early times of differentiation and plays an essential function in establishment of cell–cell adhesion. We report here that, surprisingly, Rho signaling suppresses dow...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3162 | biostudies-arrayexpress
ProteomicsSRGAP1 controls small Rho GTPases to regulate podocyte foot process maintenance
Podocyte foot process effacement and proteinuria is a common and uniform consequence of glomerular injury. Previously it has been shown that small Rho GTPases (e.g. RAC1) are drivers of podocyte foot process effacement in glomerular diseases such as focal segmental glomerulosclerosis (FSGS). However...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-07-30 | MSV000085853 | MassIVE
ModelsOta2015 - Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs (GDI integrated)
This is a ordinary differential equation mathematical model describing the Rho GTPase cycle in which Rho GDP-dissociation inhibitors (RhoGDIs) inhibit the regulatory activities of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs) by interacting with them directly as we...
2024-09-02 | BIOMD0000000899 | BioModels
TranscriptomicsSystems Modeling of the Rho Signaling Network
Describing the architecture of robust, nonlinear cell signaling networks is essential to gain a predictive understanding of cellular behavior. The structure of the Drosophila Rho-signaling network, comprised of Rho-family GTPases, RhoGTP Exchange Factors (RhoGEFs), and RhoGTPase Activating Proteins...
ORGANISM(S): Drosophila melanogaster 
2012-12-31 | E-GEOD-18307 | biostudies-arrayexpress
GenomicsIRE1alpha cancer mutants diiferentially regulate Rho family GTPases
IRE1alpha cancer mutants diiferentially regulate Rho family GTPases
PRJNA1166305 | ENA
GenomicsHP1γ/CBX3 Promotes Lung Adenocarcinoma by Activating Rho GTPases Signaling Pathway
HP1γ/CBX3 Promotes Lung Adenocarcinoma by Activating Rho GTPases Signaling Pathway
PRJNA727321 | ENA
ProteomicsProximity interaction network of Rho GTPases by BioID in human podocytes
Rho GTPases play critical roles in regulating podocyte cytoskeleton and their alteration leads to foot process effacement. However, their signaling networks remain poorly understood. To gain better insights into Rho GTPases signaling in human podocyte, we implemented the high-throughput proximity-de...
ORGANISM(S): Homo sapiens (Human) 
2025-11-03 | PXD069844 | Pride
Bioid Rhoa Rac1 Rho gtpases Cdc42 Human podocytes 
UnknownRho GTPases, oxidation, and cell redox control.
Not available
S-EPMC4114927 | biostudies-literature
UnknownFormins as effector proteins of Rho GTPases.
Not available
S-EPMC4111664 | biostudies-literature
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