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ProteomicsRibosome heterogeneity in Drosophila melanogaster gonads through paralog-switching
Ribosomes have long been thought of as homogeneous macromolecular machines, but recent evidence suggests they are heterogeneous and could be specialised to regulate translation. Here, we have isolated ribosomal complexes and characterised their protein content across 4 tissues of Drosophila melanoga...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-07-22 | PXD026227 | Pride
Gonads Testis Tmt-ms Ribosome Paralog Drosophila melanogaster Ovary 
ProteomicsRibosome protein composition in wt and 23S+5S rRNA ribosomes
The 120-nt long 5S rRNA, is an indispensable component of cytoplasmic ribosomes in all living organisms. The functions of 5S rRNA and the reasons for its evolutionary preservation as an independent molecule remain unclear. Here we used ribosome engineering to investigate whether maintaining 5S rRNA ...
ORGANISM(S): Escherichia coli 
2020-06-18 | PXD019058 | Pride
Mass-spectrometry Ribosome Proteins 
ProteomicsA proteomic roadmap of ribosome heterogeneity during human embryonic stem cell differentiation
Recent findings suggest that the ribosome itself modulates gene expression. However, whether ribosomes change composition across cell types to control cell fate remains unknown. To determine the magnitude of ribosome heterogeneity and its functional contribution to cell fate specification, we measu...
ORGANISM(S): Homo sapiens (Human) 
2022-09-19 | PXD032904 | Pride
Differentiation Ribosome Tandem mass tags (tmt) Human embryonic stem cell 
UnknownIdentifying ribosome heterogeneity using ribosome profiling.
Not available
S-EPMC9458444 | biostudies-literature
UnknownRibosome heterogeneity in development and disease.
Not available
S-EPMC11288964 | biostudies-literature
ProteomicsIdentification of ribosome proteins bound to IRES in hypoxia
Hypoxic conditions prompt internal ribosome entry site (IRES)-mediated translation of some of the hallmark cancer genes, such as VEGF. This translational switch is extremely vital for cell survival and tumor progression. Heterogeneity in ribosomes due to the diversity of ribosomal RNA (rRNA) and pro...
ORGANISM(S): Homo sapiens (Human) 
2021-01-06 | PXD019238 | Pride
Hypoxia Cancer Ires Lc-ms Ribosome 
GenomicsRegulation of ribosome hibernation controls Legionella survival, virulence, antibiotics tolerance, and phenotypic heterogeneity
Regulation of ribosome hibernation controls Legionella survival, virulence, antibiotics tolerance, and phenotypic heterogeneity
PRJEB104262 | ENA
UnknownSystematic Review of Plant Ribosome Heterogeneity and Specialization.
Not available
S-EPMC7332886 | biostudies-literature
UnknownRibosome heterogeneity in Drosophila melanogaster gonads through paralog-switching.
Not available
S-EPMC8887423 | biostudies-literature
ProteomicsRevealing Stress Granule Compositional Heterogeneity through Antibody-Guided Proximity Labeling
Stress granules (SGs), transient nonmembranous cytoplasmic condensates that formed in response to cellular stresses, require precise characterization to unravel their cell-type and stressspecific protein compositions. This study introduced a G3BP1 antibody-guided proximity labeling (Ab-PL) method to...
ORGANISM(S): Homo Sapiens (human) Mus Musculus (mouse) 
2025-11-21 | PXD070978 | JPOST Repository
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