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In this study, we demonstrated the use of the RNA Antisense Purification by Mass Spectrometry (RAP-MS) method to identify proteins involved in specific alternative splicing events. Specifically, we applied the RAP-MS method to identify proteins that interact with the Tau pre-mRNA around its exon 10 ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD023523 | Pride
Despite the prevalence of antisense transcripts in bacterial transcriptomes, little is known about how their synthesis is controlled. We report that a major function of the Escherichia coli termination factor Rho and its co-factor NusG is suppression of ubiquitous antisense transcription genome-wide...
ORGANISM(S): Escherichia coli K-12 
RNA Antisense Purification and Mass Spectrometry (RAP-MS) was performed to explore the potential RNA binding proteins of lncRNA KIMAT1
ORGANISM(S): Homo sapiens (Human) 
2021-03-01 | PXD024388 | Pride
Spt6 is a highly conserved histone chaperone that interacts directly with both RNA polymerase II and histones to regulate gene expression. To gain a comprehensive understanding of the requirements for this critical factor, we have performed genome-wide analyses of transcription, chromatin structure...
ORGANISM(S): Schizosaccharomyces pombe 
Recent studies have revealed the importance of long noncoding RNAs (lncRNAs) as tissue-specific regulators of gene expression. There is ample evidence that distinct types of vasculature undergo tight transcriptional control to preserve their structure, identity, and functions. We determined, for the...
ORGANISM(S): Homo sapiens (Human) 
2020-12-21 | PXD018578 | Pride
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Schizosaccharomyces pombe 
Background: The lack of obvious symptoms of early gastric cancer (GC) as well as the absence of sensitive and specific biomarkers results in poor clinical outcomes. Tubulin is currently emerging as important regulators of the microtubule cytoskeleton and thus have a strong potential to be implicated...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD040199 | Pride
In neurons, mRNAs and associated RNA-binding proteins assemble into ribonucleoprotein (RNP) granules essential to regulate mRNA trafficking, local translation, and turnover. Dysregulation of RNA-protein condensation can disturb synaptic plasticity. We report that the novel lncRNA mimi is a constitut...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-10-12 | PXD034457 | Pride
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Schizosaccharomyces pombe 
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