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TranscriptomicsComparison of small RNA levels in Dicer helicase mutants
Years after the discovery that Dicer is a key enzyme in gene-silencing, the role of its helicase domain remains enigmatic. Here we show that this domain is critical for accumulation of certain endogenous small interfering RNAs (endo-siRNAs) in C. elegans. The domain is required for the production of...
ORGANISM(S): Caenorhabditis elegans 
2010-04-01 | E-GEOD-20336 | biostudies-arrayexpress
TranscriptomicsThe ERI-6/7 helicase acts at the first stage of an siRNA amplification pathway that targets recent gene duplications.
To characterize the role of the ERI-6/7 helicase in endogenous small RNA pathways in C. elegans, small RNA populations from null alleles of eri-6 and eri-7, and from mutants of known endogenous RNAi pathway factors, eri-1 and ergo-1, were determined by deep sequencing, and compared to wild type. Sma...
ORGANISM(S): Caenorhabditis elegans 
2011-09-25 | E-GEOD-32366 | biostudies-arrayexpress
ProteomicsRole of Has1 RNA helicase in ribosome biogenesis in yeast S. cerevisiae
The RNA helicase Has1 is involved in the biogenesis of both small and large ribosomal subunit. How it performs these separate roles is not fully understood. We analysed a detailed composition of RNA-protein complexes purified via Has1.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-09-09 | PXD013263 | Pride
Rna processing Yeast Ribosome biogenesis Rna helicase 
TranscriptomicsTumor Cell Survival Dependence on the DExH-Box Helicase DHX9
The ATP-dependent DExH/D-box helicase DHX9 is a key participant in a number of gene regulatory steps, including transcriptional, translational, microRNA-mediated control, DNA replication, and maintenance of genomic stability. DHX9 has also been implicated in maintenance of the tumorigenic process an...
ORGANISM(S): Mus musculus 
2016-05-19 | E-GEOD-76765 | biostudies-arrayexpress
ProteomicsMolecular mechanisms of recruitment, function and regulation of the RNA helicase UPF1 in replication-dependent histone mRNA decay
Metazoan histone mRNAs are a unique class of mRNAs that lack the poly(A) tail present in all other eukaryotic transcripts. Instead, they end in a conserved stem-loop (SL) structure, necessitating a decay mechanism that is distinct from deadenylation-initiated degradation. Here, combining cryoEM with...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD070077 | Pride
Exoribonuclease 3’hexo Cxms Rna helicase upf1 Cryoem Histone mrna decay Slbp 
ProteomicsTranslational repression of the Drosophila nanos mRNA involves the RNA helicase Belle and RNA coating by Me31B and Trailer hitch
The maternal mRNA nanos is required for anterior-posterior patterning in the early Drosophila melanogaster development. The nanos-mRNA is translationally repressed and deadenylated during the first two hours of embryogenesis. A stem-loop structure in the 3'-UTR of this RNA (SRE - Smaug recogniiton e...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2017-07-18 | PXD006596 | Pride
Cup Ccr4-not-complex Deadenylation dead-box helicase Trailer hitch Nanos Me31b Translational repression Smaug 
ProteomicsRNA Helicase DDX3X Modulates Herpes Simplex Virus 1 Nuclear Egress
DDX3X is a mammalian RNA helicase that regulates RNA metabolism, cancers, innate immunity and several RNA viruses. We discovered that herpes simplex virus 1, a nuclear DNA replicating virus, highjacks redirects DDX3X to the nuclear envelope where it surprisingly modulates the exit of newly assembled...
ORGANISM(S): Homo sapiens (Human) 
2023-02-21 | PXD039403 | Pride
Herpesvirus Nec Hsv Helicase Herpes Ddx Ddx3 Host-pathogen interaction Us3 Ul31 
ProteomicsStructural basis of RNA-induced autoregulation of the DExH-type RNA helicase maleless
RNA unwinding by DExH-type helicases underlies most RNA metabolism and function. It remains unresolved if and how the basic unwinding reaction of helicases is regulated by auxiliary domains. We explored the interplay between the RecA and auxiliary domains of the RNA helicase maleless (MLE) from Dros...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2023-11-27 | PXD045725 | Pride
Helicase Qexactivehf Cl-ms Mle Rna Cx-ms Crosslinking Drosophila melanogaster 
ProteomicsInterplay between bacterial RNA 5'-termini deNADding protein NudC and DEAD-box RNA helicase CsdA in stress-responses
Nicotinamide adenine dinucleotide (NAD) "cap" recently discovered in bacteria could have similar functions as eukaryotic 7-methylguanine (m7G) "cap", which protects RNA 5'-terminus from degradation and mediates RNA interactions with proteins involved in its transportation, editing and translation. T...
ORGANISM(S): Escherichia Coli (ncbitaxon:562) 
2022-07-10 | MSV000089861 | MassIVE
ProteomicsCRISPR screening reveals that RNA helicase DDX41 triggers ribosome biogenesis and cancer progression through R-loop-mediated RPL/RPS transcription
The RNA helicase DDX41 is a DEAD-box helicase that is well known as a virus sensor in dendritic cells and a tumor suppressor that is frequently mutated in myeloid neoplasms. However, the functions and relevance of DDX41 in solid tumors remain largely unexplored. In this study, through in vivo CRISPR...
ORGANISM(S): Homo Sapiens 
2024-12-23 | PXD059178 |
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