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UnknownELAC2/RNaseZ-linked cardiac hypertrophy in Drosophila melanogaster.
Not available
S-EPMC8419712 | biostudies-literature
UnknownRNase Z Oxidative Degradation Impedes tRNA Maturation and is Involved in Streptococcal Translation Regulation in Response to Oxidative Stress.
Not available
S-EPMC8549757 | biostudies-literature
TranscriptomicsEffects of HOE-1 (RNase Z/ELAC2) nuclear hyperactivation on gene expression in Caenorhabditis elegans.
We previously reported that the RNA endonculease HOE-1 (RNaseZ/ELAC2) is necessary and sufficient for activation of the mitochondrial unfolded protein response (UPRmt) in C. elegans (PMID: 35451962). To comprehensively assess the broader cellular consequences of increased nuclear activity of HOE-1, ...
ORGANISM(S): Caenorhabditis elegans 
2024-03-13 | GSE261565 | GEO
UnknownNovel ELAC2 Mutations in Individuals Presenting with Variably Severe Neurological Disease in the Presence or Absence of Cardiomyopathy.
Not available
S-EPMC9958991 | biostudies-literature
TranscriptomicsXrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription
The exonuclease torpedo Xrn2 loads onto nascent RNA 5’-PO4 ends and chases down pol II to promote termination downstream of polyA sites. We report that Xrn2 is recruited to pre-initiation complexes and “travels” to 3’ ends of genes. Mapping of 5’-PO4 ends in nascent RNA identified Xrn2 loading sites...
ORGANISM(S): Homo sapiens 
2022-11-17 | GSE217033 | GEO
UnknownZinc- and iron-dependent cytosolic metallo-beta-lactamase domain proteins exhibit similar zinc-binding affinities, independent of an atypical glutamate at the metal-binding site.
Not available
S-EPMC1134682 | biostudies-literature
UnknownGenome-wide Mapping of 5'-monophosphorylated Ends of Mammalian Nascent RNA Transcripts.
Not available
S-EPMC10518774 | biostudies-literature
ProteomicsThe mitochondrial methylation potential gates early and late ribosome assembly
S-adenosylmethionine (SAM) is the principal methyl group donor of the cell, required to modify various molecules, including DNA, RNA and proteins. Inside mitochondria, SAM is associated with several steps of mitochondrial gene expression. However, the exact role and significance of these modificatio...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-19 | PXD055907 | Pride
Sam Rna processing Elac2 Methylation Rnasep Mitochondrial ribosome Mitochondrial translation S-adenosylmethionine Samc Rnasez Adomet Slc25a26 
GenomicsXrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription
Xrn2 substrate mapping identifies torpedo loading sites and extensive premature termination of RNA pol II transcription
PRJNA896596 | ENA
GenomicsEffects of HOE-1 (RNase Z/ELAC2) nuclear hyperactivation on gene expression in Caenorhabditis elegans.
Effects of HOE-1 (RNase Z/ELAC2) nuclear hyperactivation on gene expression in Caenorhabditis elegans.
PRJNA1087453 | ENA
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