Sort   by:  
 Page size 
no omics definedTranscription profiling of resting and activated human Vg9Vd2 T cells and CD8 ab T cells
Comparing Vg9Vd2 T cells with CD8 ab T cells
To compare the responses of resting and activated human Vg9Vd2 T cells (mainly CD4-CD8-) to those of conventional CD8+ ab T cells, we used Hver2.1.1 microarrays containing ~15,000 cDNAs. CD8 T cells were chosen as the conventional counterpart of huma...
ORGANISM(S): Homo sapiens 
2010-02-28 | E-MEXP-742 | biostudies-arrayexpress
TranscriptomicsDiscovery of novel recurrent mutations and rearrangements in early T-cell precursor acute lymphoblastic leukemia by whole genome sequencing
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy of unknown genetic basis. We performed whole genome sequencing of tumour and normal DNA from 12 children with ETP ALL and assessed the frequency of somatic alterations in 52 ETP and 42 non-ETP T-ALL samples by...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-28703 | biostudies-arrayexpress
TranscriptomicsA cell atlas of human thymic development defines T cell repertoire formation
We performed single-cell RNA-sequencing to create a cell census of the human thymus during development, early childhood and adult life. We sampled 15 embryonic and fetal thymi spanning thymic developmental stages between 7 post-conception weeks (PCW) to 17 PCW, and 9 postnatal thymi from paediatric ...
ORGANISM(S): Mus musculus 
2020-02-21 | E-MTAB-8581 | biostudies-arrayexpress
TranscriptomicsDNA Methylation Analysis of Systemic Lupus Erythematosus
This study performed Illumina Methylation450 analysis of CD4+ T-cells, CD19+ B-cells and CD14+ Monocytes from lupus patients and controls. A validation cohort was further analyzed with the same platform using CD4+ T-cells, CD45RO-CD45RA+ naive T-cells, CD45RO+CD45RA- memory T-cells, and CD25+CD127-...
ORGANISM(S): Homo sapiens 
2014-07-10 | E-GEOD-59250 | biostudies-arrayexpress
TranscriptomicsCD47-dependent immunomodulatory and angiogenic activities of extracellular vesicles produced by T cells
Intercellular communication is critical for integrating complex signals in multicellular eukaryotes. Vascular endothelial cells and T lymphocytes closely interact during the recirculation and trans-endothelial migration of T cells. In addition to direct cell-cell contact, we show that T cell deriv...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-56825 | biostudies-arrayexpress
ProteomicsFoxp3 positive and negative cell comparison
Regulatory T cells have been shown to adopt a catabolic metabolic programme with increased capacity for fatty acid oxidation fuelled oxidative phosphorylation (OXPHOS). The role of Foxp3 in this metabolic shift is poorly understood. Here we show that Foxp3 was sufficient to induce a significant incr...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-15 | PXD001789 | Pride
Mouse t cells 
TranscriptomicsT cell receptor dependent transformation of mature memory phenotype T cells
A fundamental goal in cancer research is identification of the cell types and signaling pathways capable of initiating and sustaining tumor growth as this has the potential to reveal features that can be exploited therapeutically. Stem and progenitor cells have been implicated in the genesis of s...
ORGANISM(S): Mus musculus 
2011-11-01 | E-GEOD-29732 | biostudies-arrayexpress
GenomicsThe genomic complexity of early T-cell progenitor acute lymphoblastic leukemia

CREST

The accurate identification of structural variations using whole-genome DNA sequencing data generated by next-generation sequencing technology is extremely difficult. To address this challenge, we have developed CREST, an algorithm that uses sequencing reads with partial align...

phs000340.v2.p1 | EGA
TranscriptomicsGenome-wide replication analysis of a yeast eco1 mutant by deep sequencing.
Eco1 is the acetyltransferase that establishes sister-chromatid cohesion during DNA replication. Budding yeast with an eco1 mutation that genocopies Roberts syndrome displaysreduced ribosomal DNA (rDNA) transcription and a transcriptional signature of starvation. Weshow that deleting FOB1, a gene en...
ORGANISM(S): Saccharomyces cerevisiae 
2014-04-03 | E-GEOD-54742 | biostudies-arrayexpress
UnknownComplex cerebrovascular diseases in Roberts syndrome caused by novel biallelic ESCO2 variations.
Not available
S-EPMC10265053 | biostudies-literature
Sort   by:  
 Page size