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ProteomicsCdk1 Gates Cell Cycle-Dependent tRNA Synthesis by Regulating RNA Polymerase III Activity
tRNA genes are transcribed by RNA polymerase III (RNAPIII). During recent years it has become clear that RNAPIII activity is strictly regulated by the cell in response to environmental cues and the homeostatic status of the cell. However, the molecular mechanisms that control RNAPIII activity to reg...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-10-19 | PXD011084 | Pride
Transcription Cdk1 Trna Cell cycle 
ProteomicsTORC1 shapes the SUMO proteome to control RNA Polymerase III activity
Loss of nutrient supply elicits alterations of the SUMO proteome and sumoylation is crucial to various cellular processes including transcription. However, the physiological significance of sumoylation of transcriptional regulators is unclear. To begin clarifying this, we mapped the SUMO proteome un...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-01-21 | PXD005142 | Pride
Transcription Sumoylation Rna polymerase Saccharomyces cerevisiae Chip-seq Lc-ms/ms 
ProteomicsA cell competition-based drug screen identifies a novel compound that induces dual c-Myc degradation and p53 activation
BCR-Abl is a driver oncogene that causes chronic myeloid leukemia and a subset of acute lymphoid leukemias. Although tyrosine kinase inhibitors provide an effective treatment for these diseases, they generally do not kill leukemic stem cells. Leukemic stem cells are cancer-initiating cells that comp...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-07 | PXD018812 | Pride
Leukemia C-myc Drug screening Anticancer drug Abl tyrosine kinase Phosphoproteomics Mrna P53 
UnknownActive idiotypic vaccination versus control immunotherapy for follicular lymphoma.
Not available
S-EPMC4039868 | biostudies-literature
ProteomicsProteomic/phosphoproteomic analysis of isolated adhesion complexes
Combined proteomic and phosphoproteomic analysis of adhesion complexes isolated from cells adherent to the ECM protein fibronectin. A total of 1109 phosphorylation sites were detected, including both known and novel adhesion-induced signalling events.
ORGANISM(S): Homo sapiens (Human) 
2016-06-29 | PXD001578 | Pride
Proteomics Signalling Adhesion Phosphoproteomics Integrin 
UnknownIn-situ microfluidic controlled, low temperature hydrothermal growth of nanoflakes for dye-sensitized solar cells.
Not available
S-EPMC4668546 | biostudies-literature
UnknownResponding to eruptive transitions during the 2020-2021 eruption of La Soufriere volcano, St. Vincent.
Not available
S-EPMC9287448 | biostudies-literature
UnknownIntervertebral disc degeneration is rescued by TGFβ/BMP signaling modulation in an ex vivo filamin B mouse model.
Not available
S-EPMC9042866 | biostudies-literature
UnknownRefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape.
Not available
S-EPMC3136255 | biostudies-literature
UnknownMachine learning to attribute the source of Campylobacter infections in the United States: A retrospective analysis of national surveillance data.
Not available
S-EPMC7617841 | biostudies-literature
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