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TranscriptomicsIntegrative miRnome and transcriptome analysis in human malignant prolactin pituitary tumors identify miR-183 as driving gene for tumor progression to malignancy.
miRNAs expression is known to be deregulated in many types of cancer leading to suspect them implication in crucial steps occurring during tumor progression and maybe as potential driving genes. In this study we tried to decipher the place of miRNA in the hierarchical events cascade occurring in pr...
ORGANISM(S): Homo sapiens 
2015-05-01 | E-GEOD-46294 | biostudies-arrayexpress
TranscriptomicsTranscriptomic dysregulation in aggressive and malignant prolactin tumours
Pituitary tumours are generally benign. However, many are invasive and some of these are aggressive with high proliferation and recurrence rates. Only metastatic tumours are considered malignant and are rare (0.2%). To identify molecular events associated with the aggressive and malignant phenotypes...
ORGANISM(S): Homo sapiens 
2011-03-16 | E-GEOD-22812 | biostudies-arrayexpress
TranscriptomicsGenomic alterations of chromosome 11 induce transcriptomic dysregulation in aggressive and malignant prolactin tumours
Pituitary tumors are generally considered as benign. However, many are invasive (45 to 55%) and some are described as aggressive with a high proliferation rate and short post-operative time to recurrence and 0.2% metastasize. The molecular events associated to the progression of the pituitary tumor ...
ORGANISM(S): Homo sapiens 
2011-03-16 | E-GEOD-22615 | biostudies-arrayexpress
TranscriptomicsGene expression regionalization in the outflow tract of the mouse heart
Gene expression profiling of the inferior and superior wall of the distal midgestation arterial domain (outflow tract) of the wild type CD1 mouse embryonic heart Total RNA was recovered from dissections of the inferior and superior OFT subdomains of Mus musculus littermate embryonic hearts at day 10...
ORGANISM(S): Mus musculus 
2014-10-15 | E-GEOD-57951 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Acanthamoeba polyphaga mimivirus infecting Acanthamoeba castellanii for different lengths of time
A culture of Acanthamoeba castellanii cells was infected with mimivirus. At specified times after infection, infected cells aliquots were subjected to total RNA extraction. Cy3 labeled cDNA was hybridized on custom designed Agilent oligonucleotide tiling microarrays covering both strands of the mimi...
ORGANISM(S): Acanthamoeba polyphaga mimivirus 
2010-03-18 | E-MTAB-187 | biostudies-arrayexpress
ProteomicsQuantitative proteomic profiling of Arabidopsis nuclei reveals accumulation of nucleolar proteins after a prolonged heat stress
Heat stress (HS) impacts the nuclear proteome and, subsequently, protein activities in the nucleoplasm and/or different nuclear compartments. In Arabidopsis thaliana, a short exposure to 37°C leads to the loss of the standard tripartite architecture of the nucleolus, the most prominent nuclear subst...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-10-17 | PXD045038 | Pride
Nanolc-msms Heat stress Nucleolus Nucleus 
TranscriptomicsMicroarray on cell populations sorted from the imiquimod-treated skin
The imiquimod model is used to induce the skin production of IL-22 and to characterize the cells that produce IL-22 in the skin after inflammatory stimulus. This experiment is performed on skin of C57Bl/6 mice treated with imiquimod to induce psoriasis-like lesions. After 5 days of imiquimod treatme...
ORGANISM(S): Mus musculus 
2016-08-09 | E-MTAB-4453 | biostudies-arrayexpress
TranscriptomicsDevelopment of Laser Capture Microdissection to study the gene expression of the sheep early ovarian folliculogenesis
Background Correct achievement of early ovarian folliculogenesis is a crucial phase for further ovarian function. This process is closely regulated by cell-cell interactions and coordinated expression of genes from oocyte and granulosa cells. But, despite of the large number of studies, little is kn...
ORGANISM(S): Bos taurus 
2011-07-01 | E-GEOD-25652 | biostudies-arrayexpress
TranscriptomicsmRNA profiling by array for pancreatic ductal adenocarcinoma for clinical application
We performed combined gene expression analysis and targeted gene sequencing of 309 consecutive patients from a multicenter consortium.
ORGANISM(S): Homo sapiens 
2018-09-04 | E-MTAB-6134 | biostudies-arrayexpress
GenomicsActive STAT5 in CD8 T cells imprints a T-Bet-dependent Tc-1 program with repressed IL-6/ TGFb1 signaling leading to enhanced anti-tumor responses
CD8 T cells (TCs) expressing active STAT5 (STAT5CA) transcription factors were found to be superior to un-manipulated counterparts in their long-term persistence, capacity to infiltrate a tumor, thrive in its microenvironment and induce its regression. STAT5CA induced sustained expression of genes c...
ORGANISM(S): Mus musculus 
2013-09-13 | E-GEOD-41818 | biostudies-arrayexpress
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