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MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
ProteomicsTranscriptomic and Proteomic Insight into the Mechanism of Cyclooctasulfur- versus Thiosulfate-Oxidation by the Chemolithoautotroph Sulfurimonas denitrificans
Chemoautotrophic bacteria belonging to the genus Sulfurimonas in the class Campylobacteria (formerly classified as Epsilonproteobacteria) play a key role in the sulfur cycle in a variety of oxygen-deficient or –limited and sulfide-rich marine and terrestrial environments. Previously, they were ident...
ORGANISM(S): Sulfurimonas denitrificans 
2019-07-22 | PXD009127 | Pride
Sulfur Campylobacteria Proteomics Oxidation Epsilonproteobacteria 
TranscriptomicsRNA-seq of human cancer cell lines HCT116, T47D and A549 in 3D collagen I microenvironments compared to 2D cell culture
The behavior of cancer cells strongly relies on the properties of the extracellular microenvironment. The aim was to compare the whole transcriptome of three non-invasive cancer cell lines, HCT-116, A549 and T-47D, embedded in collagen I matrices in a time-dependent manner to standard two-dimensiona...
ORGANISM(S): Homo sapiens 
2026-07-31 | E-MTAB-16838 | biostudies-arrayexpress
ProteomicsMicroglial proteomic signatures in APPPS1 and APP-KI mice
Microglial dysfunction is a key pathological feature of Alzheimer´s disease (AD), but little is known about proteome-wide changes in microglia during the course of AD pathogenesis and their consequences for microglial function. Here, we performed an in-depth proteomic characterization of microglia i...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-09 | PXD016075 | Pride
Neuroinflammation Phagocytosis Alzheimer’s disease Proteomic signatures Microglia 
TranscriptomicsRNAseq of differentiation states of primary monocytes and THP-1 cells (from two depositors)
Intensive usage of cancer cell lines as cellular model system in cancer research caused the generation of variant subtypes during the last decades. This study focused on the human leukemic THP-1 cell line as a monocyte model. THP-1 cells from two different depositors were differentiated into variou...
ORGANISM(S): Homo sapiens 
2026-07-24 | E-MTAB-17225 | biostudies-arrayexpress
UnknownPannexin 1 and pannexin 3 differentially regulate the cancer cell properties of cutaneous squamous cell carcinoma.
Not available
S-EPMC12333905 | biostudies-literature
ProteomicsLC-MS/MS analysis of isolated murine brain endothelial cells (EC) and full brain tissue (FT) preparations from 3-months-old mice followed by label-free quantification (LFQ)
Age-related decline in brain endothelial cell (BEC) function critically contributes to cerebrovascular and neurodegenerative disease. Comprehensive atlases of the BEC transcriptome have become available but results from proteomic profiling are lacking. To gain insights into endothelial pathways affe...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-15 | PXD044993 | Pride
Macs Brain endothelial cells 
ProteomicsA proteomics resource for human iPSC-derived endothelial cells (iEC) - human FOXF2 KO versus WT control
FOXF2, a major risk gene for stroke and SVD, the mechanisms of which are insufficiently understood. CRISPR/Cas9-mediated knockout of FOXF2 induced key features of BBB dysfunction, including compromised cell junction integrity, decreased transendothelial electrical resistance and dysregulated caveola...
ORGANISM(S): Homo sapiens (Human) 
2025-09-02 | PXD051960 | Pride
Small vessel disease Foxf2 Ipsc Endothelial cells 
ProteomicsLC-MS/MS analysis of AAV-treated ARF6-KO vs WT and APOE-KO human induced endothelial cells (iECs) followed by label-free quantification (LFQ)
Age-related decline in brain endothelial cell (BEC) function critically contributes to cerebrovascular and neurodegenerative disease. Comprehensive atlases of the BEC transcriptome have become available but results from proteomic profiling are lacking. To gain insights into endothelial pathways affe...
ORGANISM(S): Homo sapiens (Human) 
2024-02-15 | PXD045026 | Pride
Human Arf6 Ipsc Endothelial cells 
ProteomicsProteogenomics analysis unveils a novel TFG-RET gene fusion and druggable targets in papillary thyroid carcinomas
Papillary thyroid cancer (PTC) is the most common type of endocrine malignancy. From a set of PTC patients whose tumor did not harbour any BRAF or RAS mutations, a 35 years old male patient’s normal, primary tumor and lymph node (LN) metastatic tissues was subjected to genomics and proteomics analys...
ORGANISM(S): Homo sapiens (Human) 
2020-04-02 | PXD016739 | Pride
Precision medicine Tfg-ret Ptc Ret Usp9x Huwe1 Usp7 
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