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MetabolomicsMicrobiota-derived metabolites act as ecological effectors of colonization resistance against Salmonella Enteritidis

Colonization resistance is a fundamental ecological function of the gut microbiota that limits the expansion of enteric pathogens. Yet, the microbial effectors linking ecosystem homeostasis to pathogen control remain poorly understood. Here, we demonstrate that Salmonella Enteritidis (S. Enteriti...

2026-08-31 | MTBLS15505 | MetaboLights
TranscriptomicsRole of SPI-1 Secreted Effectors, SipA, SopABDE2, in Acute Bovine Response to Salmonella enterica Serovar Typhimurium
Salmonella enterica Serovar Typhimurium (S. Typhimurium) causes enterocolitis in humans and calves characterized by diarrhea and polymorphonuclear cell (PMN) influx to the intestinal mucosa. The Salmonella Type III Secretion System encoded at Pathogenicity Island I (SPI-1) translocates the Salmonel...
ORGANISM(S): Bos taurus 
2012-01-10 | E-GEOD-13847 | biostudies-arrayexpress
TranscriptomicsEffects of nitric oxide on Salmonella adapted at pH 4.4
Reactive nitrogen species (RNS) derived from dietary and salivary inorganic nitrates (NO3-) foment innate host defenses associated with the acidity of the stomach. The mechanisms by which these reactive species exert antibiotic activity in the gastric lumen are, however, poorly understood. To iden...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2010-05-26 | E-GEOD-9398 | biostudies-arrayexpress
ProteomicsArg-GlcNAcylation of Salmonella proteins
This project explores the impact of SseK mediated Arg-GlcNAcylation on Salmonella proteins. Using Site directed mutagenesis, MS analysis and phenotypic studies we show Arg-GlcNAcylation appears to modulate the functions of multiple salmonella enzymes. This work demonstrates effectors can have multip...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. ST1489 
2021-09-09 | PXD021878 | Pride
Salmonella Glycosylation Arg-glcnacylation Effectors 
TranscriptomicsGenome-wide screen for salmonella genes required for long-term systemic infection of the mouse.
This datasets includes all arrays from the first passage through 129SvJ mice (28 days) and the second independent passage (29 days). The first passage arrays are the same as included in the experiment set "129SvJ Pass 1 28 dpi arrays" and the second passage arrays are the same as included...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2006-03-14 | E-GEOD-4461 | biostudies-arrayexpress
TranscriptomicsGlobal impact of Salmonella type III secretion effector SteA on host cells
Salmonella enterica is a Gram-negative bacterium that causes gastroenteritis, bacteremia and typhoid fever in several animal species including humans. Its virulence is greatly dependent on two type III secretion systems (T3SSs), encoded in pathogenicity islands 1 (SPI1) and 2 (SPI2), respectively. T...
ORGANISM(S): Homo sapiens 
2014-05-28 | E-GEOD-51043 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of 14 regulators required for Salmonella virulene
To cause a systemic infection, Salmonella must respond to many environmental cues during mouse infection and express specific subsets of genes in a temporal and spatial manner, but the regulatory pathways are poorly established. To unravel how micro-environmental signals are processed and integrated...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S 
2012-05-30 | E-GEOD-38378 | biostudies-arrayexpress
Proteomicsidentification of the endogenous host targets of the Salmonella effectors SSeK1 and 3
Strains of Salmonella utilise two distinct type three secretion systems to deliver effector proteins directly into host cells. The Salmonella effectors SseK1 and SseK3 are arginine glycosyltransferases that modify mammalian death domain containing proteins with N-acetyl glucosamine (GlcNAc) when ove...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 
2019-03-27 | PXD010769 | Pride
Glycosylation Salmonella Proteomics Infection Glycopeptide enrichment 
ProteomicsHost targets of Salmonella secreted effectors
Identification of mouse proteins targeted by Salmonella secreted effectors by affinity purification followed by mass spectrometry.
ORGANISM(S): Mus musculus (Mouse) 
2020-04-03 | PXD004002 | Pride
Host targets Type 3 secretion system Effectors 
TranscriptomicsDual RNA-seq – sRNA profiling in various cell types
Bacteria possess many small noncoding RNAs whose regulatory roles in pathogenesis are little understood due to a paucity of macroscopic phenotypes in standard virulence assays. Here, we use a novel Dual RNA-seq approach for a single-step simultaneous RNA profiling in both pathogen and host to reveal...
ORGANISM(S): mixed sample: human cell line CaCo-2 and Salmonella Typhimurium SL1344 
2015-12-11 | E-GEOD-67947 | biostudies-arrayexpress
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