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This project explores the impact of SseK mediated Arg-GlcNAcylation on Salmonella proteins. Using Site directed mutagenesis, MS analysis and phenotypic studies we show Arg-GlcNAcylation appears to modulate the functions of multiple salmonella enzymes. This work demonstrates effectors can have multip...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. ST1489 
2021-09-09 | PXD021878 | Pride
Analysis of OmpR Arg-GlcNAcylation using bottom up proteomic analysis
ORGANISM(S): Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 
2023-05-20 | PXD039412 | Pride
This project explores the Arg-GlcNAcylation on Salmonella proteins GlmR and NagC. Using MS analysis and Site directed mutagenesis we show Arg-GlcNAcylation occurs on these salmonella enzymes.
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium str. SL1344 
2022-03-10 | PXD030710 | Pride
Many Gram-negative bacterial pathogens interact with mammalian cells by using type III secretion systems (T3SS) to inject virulence proteins directly into infected host cells. A subset of these injected protein ‘effectors’ are enzymes that modify the structure and inhibit the function of human prote...
ORGANISM(S): Escherichia coli 
2020-01-14 | PXD015752 | Pride
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