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ProteomicsSingle-Cell and Proteomic Profiling Identify Cav-1β Expression during Human Plasma Cell Differentiation and Its Association with the V-ATPase–RAGulator–RAG Complex
Human B cell differentiation into memory B cells and antibody-secreting plasma cells (PCs) involves coordinated transcriptional and cellular remodeling. Using an optimized in vitro differentiation system combined with single-cell transcriptomics, we reconstructed human B cell differentiation traject...
ORGANISM(S): Homo sapiens (Human) 
2026-09-18 | PXD079880 | Pride
Secretory machinery of pcs Mtorc signaling Cav1 network Er remodeling program 
ProteomicsFirst identification of a large set of serine hydrolases by activity-based protein profiling in dibutyl phthalate-exposed zebrafish larvae
Despite the involvement of several serine hydrolases (SHs) in the metabolism of xenobiotics such as dibutyl phthalate (DBP), no study has focused on mapping this enzyme class in zebrafish, a model organism frequently used in ecotoxicology. Here, we survey and identify active SHs in zebrafish larvae ...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2023-03-11 | PXD038229 | Pride
Proteomics Zebrafish larvae Activity-based protein profiling Serine hydrolases Dibutyl phthalate 
ProteomicsComprehensive analysis of transcripts and proteins relative abundance during Plasmodium falciparum blood stages
We aimed to evaluate the relevance of mRNA study as a proxy of protein expression in sequestered parasites. To do so, we conducted a proteotranscriptomic analysis using five independent P. falciparum laboratory strains samples. RNA sequencing was performed on circulating ring stage parasites and LC-...
ORGANISM(S): Plasmodium falciparum 
2021-02-10 | PXD020052 | Pride
Plasmodium falciparum  rna-seq  fpkm  lc-ms/ms  label free quantification  transcriptomes  proteomes  transcripts and proteins expression correlation 
ProteomicsInfected erythrocytes and plasma proteomics reveal a specific protein signature of severe malaria.
Severe malaria (SM) is a life-threatening condition caused by Plasmodium falciparum and the most severe presentation is cerebral malaria (CM) mostly affecting children under five years old. The comprehensive understanding of the complex mechanisms driving the pathophysiology of CM, which encompasses...
ORGANISM(S): Homo sapiens (Human) Plasmodium falciparum 
2024-02-01 | PXD042503 | Pride
Infected erythrocytes Severe malaria Plasma Infected erythrocytes severe malaria Plasmodium falciparum Lc-ms/ms 
ProteomicsGlyoxal induces senescence of human keratinocytes through oxidative stress and activation of the AKT/FOXO3a/p27KIP1 pathway
Senescence is a well-known cellular event characterized by specific markers like a permanent cell proliferation arrest and the secretion of messenger molecules forming the Senescence-Associated Secretory Phenotype (SASP). The SASP composition depends on many factors such as the cell type or the natu...
ORGANISM(S): Homo sapiens (Human) 
2022-01-03 | PXD025184 | Pride
Sasp Keratinocytes Advanced glycation end products Cellular senescence Glyoxal Oxidative stress Dicarbonyl stress Secretory phenotype 
ProteomicsImpact of fetal growth restriction on neonatal microglia proteome in rat.
Microglia activation is a key modulator of brain vulnerability in response to intra-uterine growth restriction (IUGR). However, the consequences of IUGR on microglia development and on microglia proteome are still unknown. We used a model of IUGR induced by a gestational low-protein diet (LPD) in ra...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-12-17 | PXD028950 | Pride
Microglia  iugr  inflammation  proteome  brain development  mass spectrometry 
ProteomicsProteomic analysis of reticulocytes treated with the PIEZO-1 activator YODA
We performed a label free proteomic analysis on reticulocytes produced in vitro from CD34+ of healthy donors cells either exposed to DMSO as a control or to the PIEZO1 activator YODA1 at 1µM.
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035122 | Pride
Reticulocytes Mechanotransduction Piezo1 Xerocytosis Proteomic 
UnknownIdentification and functional validation of intracellular protein partners of phosphorothioate splice-switching oligonucleotides using AP-MS.
Not available
S-EPMC12860984 | biostudies-literature
ProteomicsG-CSF reshapes the cytosolic PCNA scaffold and modulates glycolysis in neutrophils
The balance between neutrophil survival and apoptosis must be tightly regulated to avoid exaggerated inflammatory responses. Cytosolic proliferating cell nuclear antigen (PCNA) is involved in neutrophil survival and function, where it acts as a scaffold and associates with proteins involved in NADPH...
ORGANISM(S): Homo sapiens (Human) 
2024-02-15 | PXD043496 | Pride
Pcna Neutrophil Survival G-csf Glycolysis 
UnknownFirst Identification of a Large Set of Serine Hydrolases by Activity-Based Protein Profiling in Dibutyl Phthalate-Exposed Zebrafish Larvae.
Not available
S-EPMC9786740 | biostudies-literature
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