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Gamete quality is one of the most important element of successful aquaculture. This especially applies to a newly domesticated fish species, such as pikeperch (Sander lucioperca) in which lowered and/or variable egg quality is one of the biggest obstacles toward rapid production expansion. However, ...
ORGANISM(S): Sander lucioperca 
2021-11-03 | PXD023229 | Pride
The project aims to evaluate the contribution of ADAR1 RNA editing to B cell lymphomagenesis, specifically in diffuse large B cell lymphoma (DLBCL). Within our DLBCL cohort, RNA editing targets transcripts within known lymphoma-driving pathways such as apoptosis, p53 and NF-kB signaling, as well as ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD041549 | Pride
In Burkitt lymphoma (BL), an aggressive germinal-center (GC) derived non-Hodgkin B-cell lymphoma characterized by MYC translocations as early transforming event, the apoptotic properties of MYC must have been overcome by pro-survival signals. Whereas activation of the pro-survival factor NFkappaB is...
ORGANISM(S): Mus musculus 
PI3K signaling and FOXO transcription factors play opposing roles at several B cell developmental stages. We show here abundant nuclear FOXO1 expression in the proliferative compartment of the germinal center (GC), its dark zone (DZ), and PI3K activity, downregulating FOXO1, in the GC light zone (LZ...
ORGANISM(S): Mus musculus 
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