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ProteomicsClassical virulence factors do not define Cryptococcus pathogenic diversity
Pathogenic determinants in the Cryptococcus genus have been extensively studied, often using standard laboratory isolates. Here, we analyzed the virulence of ten Cryptococcus isolates from diverse sources, species, and genotypes. These isolates exhibited marked differences in their ability to coloni...
ORGANISM(S): Cryptococcus gattii VGII R265 Cryptococcus neoformans var. neoformans JEC21 
2025-10-20 | PXD065863 | Pride
Diversity Virulence Pathogenic Cryptococcus 
ProteomicsProteomics reveals that the antifungal activity of fenbendazole against Cryptococcus neoformans requires protein kinases.
Cryptococcus neoformans is responsible for over 100,000 deaths annually, and the treatment of this fungal disease is expensive and not consistently effective. Unveiling new therapeutic avenues is crucial. Previous studies have suggested that the anthelmintic drug fenbendazole is an affordable and n...
ORGANISM(S): Cryptococcus neoformans var. grubii serotype A (strain H99 / ATCC 208821 / CBS 10515 / FGSC 9487) (Filobasidiella neoformans var. grubii) 
2024-05-21 | PXD047041 | Pride
Cryptococcus neoformans  antifungal activity  fenbendazole  proteomics  protein kinases 
ProteomicsCellular and molecular responses of Cryptococcus to brilacidin (MMV1634402) and KIN1400 (MMV019724)
Cryptococcosis is a systemic mycosis caused by Cryptococcus neoformans and C. deuterogattii. Available therapeu-tic options are limited and face several challenges, including high toxicity, the emergence of resistant strains, high costs, and restrict-ed distribution. In this study, we evaluated the ...
ORGANISM(S): Cryptococcus neoformans H99-YPD_1 
2026-09-07 | PXD070309 | Pride
Cryptococcus neoformans Proteomics. Biofilm Cryptococcus deuterogattii Cryptococcosis Antifungal drugs syner-gism Antifungal activity 
ProteomicsFungal extracellular vesicles are recoverable across variable ultracentrifugation speeds but display species-specific profiles of sedimentation
Extracellular vesicles (EVs) are central components of fungal biology, yet their isolation commonly relies on ultracentrifugation schemes originally developed for mammalian systems. In Cryptococcus, most EVs carry the capsular polysaccharide glucuronoxylomannan (GXM), raising the possibility that ve...
ORGANISM(S): Cryptococcus neoformans RCT29 
2026-06-29 | PXD076414 | Pride
Fungal extracellular  vesicles  ultracentrifugation  profiles 
ProteomicsEffects of human immunoglobulins on Cryptococcus neoformans morphology and proteome
Cryptococcus neoformans (Cn) is the main cause of fungal meningitis (CM) in people living with HIV. Perturbations in levels of normal immunoglobulin (Ig) levels are observed in these individuals, but their association with CM pathogenesis is unclear. Here, we investigated the physical and biological...
ORGANISM(S): Cryptococcus neoformans 
2026-01-26 | PXD072710 | Pride
Igm Cryptococcal capsule Cryptococcus neoformans Human immunoglobulins Igg Hiv Cryptococcal proteome. And iga Glucuronoxylomannan 
ProteomicsPROTEOMICS REVEALS DIFFERENTIALLY REGULATED PATHWAYS WHEN COMPARING LOW-VERSUS HIGH-GRADE ASTROCYTOMAS
Astrocytic tumors are known for their high progression capacity and for high mortality rates; in this regard, proteins correlated to prognosis can aid medical conduct. Although several genetic changes related to progression from low to high-grade astrocytoma are already known, mRNA copies do not nec...
ORGANISM(S): Homo sapiens (Human) 
2023-08-04 | PXD033782 | Pride
Mass spectrometer Low-grade astrocytoma and high-grade astrocytoma. Proteomics 
ProteomicsProteogenomic Analysis Reveals Proteins Involved in the First Step of Adipogenesis in Human Adipose-derived Stem Cells
Background: Obesity is characterized as a disease that directly affects the whole-body metabolism and is associated with excess fat mass and several related comorbidities. Dynamics of the adipocyte hypertrophy and hyperplasia play an important role in health and disease, especially in obesity. Human...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD026299 | Pride
Differentiation Protein Adipogenic Mrna. Hasc Proteogenomics 
ProteomicsProteomic studies on the effects of the deletion of two aminophospholipid translocases in the cellular and extracellular vesicle fractions of Cryptococcus neoformans
Flippases are enzymes responsible for the architecture of eukaryotic membranes, regulating various mechanisms of molecular transport and lipid translocation. In Cryptococcus neoformans, a major fungal pathogen, the aminophospholipid translocase 1 (Apt1) flippase plays roles in fungal virulence, memb...
ORGANISM(S): Cryptococcus neoformans Tu401-MP_1 
2026-06-29 | PXD056961 | Pride
Proteomic deletiontranslocases cellular extracellular vesicle cryptococcus neoformans 
ProteomicsThe Impact of Blood-Processing Time on the Proteome of Human Peripheral Blood Mononuclear Cells
Human peripheral blood mononuclear cells (PBMC) are key to several diagnostics assays and basic science research. Blood pre-analytical variations that occur before obtaining the PBMC fraction can have a significant impact on the results of the assays, including viability, composition, integrity, and...
ORGANISM(S): Homo sapiens (Human) 
2020-12-14 | PXD021367 | Pride
Pbmc Immunology. Proteomics Itraq Blood 
ProteomicsDipeptidyl peptidase IV contributes to the pathogenesis of Cryptococcus neoformans
We previously identified isoleucine–proline–isoleucine (IPI) as a small molecule associated with extracellular vesicles (EVs) in Cryptococcus. The administration of IPI controlled experimental cryptococcal infection through mechanisms that remain unknown. IPI is an inhibitor of dipeptidyl peptidase ...
ORGANISM(S): Cryptococcus neoformans 
2026-07-17 | PXD076200 | Pride
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