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TranscriptomicsTranscription profiling of human Ewing sarcoma (A673) cells treated with cytarabine, doxorubicin and puromycin oral tongue squamous cell carcinomas to identify novel potential prognosticators
An increasing number of cancer-associated mutations have been identified. Unfortunately, little therapy today exploits these tumor-specific genetic lesions. Often, the resulting oncoproteins have been intractable to easy manipulation with current small molecule screening approaches. To overcome this...
ORGANISM(S): Homo sapiens 
2008-11-22 | E-GEOD-6930 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Kaposi sarcoma, normal skin and primary cells
Identification of the relationships of Kaposi sarcoma (KS), normal skin to various cell cultures. The effects of KS herpes virus, the infectious cause of KS, on infected endothelial cells are also investigated.
ORGANISM(S): Homo sapiens 
2004-08-01 | E-MEXP-66 | biostudies-arrayexpress
ProteomicsDiscovery-Based Protein Expression Profiling Identifies Distinct Subgroups and Pathways in Leiomyosarcomas
20 tumor samples run in duplicates, consisting of pleomorphic sarcomas; classfied as leiomyosarcoma or high-grade undifferentiated pleomorphic sarcoma.
ORGANISM(S): Homo sapiens (Human) 
2020-01-27 | PXD000616 | Pride
Sarcoma human label-free 
TranscriptomicsshRNA profiling of human Ewings sarcoma samples to produce a molecular function map of Ewinga??s Sarcoma
EWS-FLI1 is a chimeric ETS transcription factor that is, due to a chromosomal rearrangement, specifically expressed in Ewing’s sarcoma family tumors (ESFT) and is thought to be the initiating event in the development of the disease. Previous genomic profiling experiments have identified a number o...
ORGANISM(S): Homo sapiens 
2009-05-11 | E-GEOD-14543 | biostudies-arrayexpress
ProteomicsGlobal proteomics and SWI/SNF interactomics in Epithelioid Sarcoma (EpS) upon rescue of SMARCB1
DOX-dependently SMARCB1-re-expressing, stable isogenic EpS cell line models were generated and submitted to global proteomic analysis as well as interactome analysis by co-immunoprecipitation of BRG1, one of the SWI/SNF core ATPases after 96h of DOX treatment.
ORGANISM(S): Homo sapiens (Human) 
2024-12-17 | PXD053945 | Pride
Swi/snf Smarca4/brg1 Smarcb1 Epithelioid sarcoma 
ProteomicsThe Ewing sarcoma secretome and its response to activation of Wnt/beta- catenin signaling
Tumor: tumor microenvironment (TME) interactions are critical for tumor progression and the composition and structure of the local extracellular matrix (ECM) are key determinants of tumor metastasis. We recently reported that activation of Wnt/beta- catenin signaling in Ewing sarcoma cells induces w...
ORGANISM(S): Homo sapiens (Human) 
2018-02-07 | PXD007909 | Pride
Ewing sarcoma Wnt/beta-catenin Label-free mass spectrometry Extracellular matrix Secretome Tumor microenvironment 
ProteomicsA comprehensive evaluation of the Ewing sarcoma surface and global proteomes reveals actionable immunotherapeutic targets.
Ewing sarcoma (EwS) is the second most common bone sarcoma in children, with 1 case per 1.5 million in the United States. While the survival rate of patients diagnosed with localized disease is ~70%, this decreases to ~30% for patients with metastatic disease and only ~10% for treatment refractory d...
ORGANISM(S): Homo sapiens (Human) 
2023-09-29 | PXD043375 | Pride
Ewing sarcoma Surfaceome 
ProteomicsDetection of Early Prognostic Biomarkers for Metastasis of Ewing’s Sarcoma in Pediatric Patients
Ewing’s sarcoma (ES) is a highly aggressive bone tumor, and the second most prevalent pediatric bone malignancy. The presence of metastasis at diagnosis decreases the three-year survival rate to 20% and contributes to diminished prognosis. Researches are indispensable for the early characterization ...
ORGANISM(S): Homo sapiens (Human) 
2023-12-19 | PXD035812 | Pride
Ewing's sarcoma Mass spectrometry Proteomics Pediatric cancer Biomarkers 
TranscriptomicsKnockdown of KSHV viral interferon-regulatory factor 3 (vIRF-3) in primary effusion lymphoma (PEL) cells by RNA-Interference
KaposiM-bM-^@M-^Ys sarcoma-associated hepesvirus (KSHV) encodes four genes with homology to human interferon regulatory factors (IRFs). One of these IRFs, the viral interferon regulatory factor 3 (vIRF-3) is expressed in latently infected PEL cells and required for their continuous proliferation. Mo...
ORGANISM(S): Homo sapiens 
2011-01-19 | E-GEOD-26661 | biostudies-arrayexpress
TranscriptomicsShared prognostic markers in undifferentiated pleomorphic sarcoma and leiomyosarcoma of the extremities
Soft tissue sarcoma diagnostics and prognostics are challenging, particularly in highly malignant and pleomorphic subtypes such as undifferentiated pleomorphic sarcoma (UPS) and leiomyosarcoma (LMS). We applied 32K BAC-arrays and gene expression profiling to 18 extremity soft tissue LMS and 31 extre...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-13775 | biostudies-arrayexpress
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