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ProteomicsAn atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics
Aging promotes lung function decline and susceptibility to chronic lung diseases, which are the third leading cause of death worldwide. We used single cell transcriptomics and mass spectrometry to quantify changes in cellular activity states of 30 cell types and the tissue proteome from lungs of you...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-21 | PXD012307 | Pride
Lung Lipid metabolism Single cell transcriptomics Total proteome Qdsp Chronic lung disease Aging Lung cell atlas Extracellular matrix 
ProteomicsA proteomics workflow reveals predictive autoantigens in idiopathic pulmonary fibrosis (cohort 1)
Rationale: The diagnosis of idiopathic pulmonary fibrosis (IPF) requires exclusion of an underlying autoimmune disease, as present in interstitial lung diseases associated with connective tissue diseases (CTD-ILD). The prevalence of autoantibodies in IPF patients is currently unknown. Objectives: An...
ORGANISM(S): Homo sapiens (Human) 
2021-02-22 | PXD024113 | Pride
Ipf Ctd-ild Clinical proteomics Autoantibodies Autoimmunity Lung fibrosis 
ProteomicsA proteomics workflow reveals predictive autoantigens in idiopathic pulmonary fibrosis (cohort 2)
Rationale: The diagnosis of idiopathic pulmonary fibrosis (IPF) requires exclusion of an underlying autoimmune disease, as present in interstitial lung diseases associated with connective tissue diseases (CTD-ILD). The prevalence of autoantibodies in IPF patients is currently unknown. Objectives: An...
ORGANISM(S): Homo sapiens (Human) 
2021-02-22 | PXD024123 | Pride
Ipf Ctd-ild Clinical proteomics Autoantibodies Autoimmunity Lung fibrosis 
ProteomicsPredictive protein biomarker signatures and the corresponding transcriptional cell state changes in human lung fibrosis
Single cell genomics enables characterization of disease specific cell states, while improvements in mass spectrometry workflows bring the clinical use of body fluid proteomics within sight. However, the correspondence of peripheral protein signatures with cell state changes in diseased organs is cu...
ORGANISM(S): Homo sapiens (Human) 
2020-09-18 | PXD017145 | Pride
Data integration Proteomics Fibrosis Single cell rna-seq Systems medicine Biomarker 
ProteomicsTime and compartment resolved proteome profiling of the extracellular niche in lung injury and repair
The extracellular niche is a key regulator of tissue morphogenesis and repair, however, its composition is currently not well characterized. Quantitative mass spectrometry resolved the dynamics of 8366 proteins from total tissue and bronchioalveolar lavage fluid in the consecutive phases of repair u...
ORGANISM(S): Mus musculus (Mouse) 
2015-07-21 | PXD001765 | Pride
Regeneration Proteomics Matrisome Fibrosis Repair 
ProteomicsPredictive protein biomarker signatures and the corresponding transcriptional cell state changes in human lung fibrosis (Plasma)
Single cell genomics enables characterization of disease specific cell states, while improvements in mass spectrometry workflows bring the clinical use of body fluid proteomics within reach. However, the correspondence of peripheral protein signatures to changes in cell state in diseased organs is c...
ORGANISM(S): Homo sapiens (Human) 
2020-09-18 | PXD017210 | Pride
Data integration Proteomics Fibrosis Single cell rna-seq Systems medicine Biomarker 
ProteomicsPhosphoproteomics of cellular mechanosensing reveals NFATC4 as a regulator of myofibroblast activity
Feedback connections between tissue stiffness and cellular contractile forces can instruct cell identity and activity via a process referred to as mechanosensing. Specific phosphoproteome changes during mechanosensing are poorly characterized. In this work, we chart the global phosphoproteome dynami...
ORGANISM(S): Homo sapiens (Human) 
2026-06-02 | PXD063448 | Pride
Human lung fibroblast 
ProteomicsM.musculus - Lung, iBAQ (Angelidisetal,natcommun.2019)
abundance based on iBAQ, Interaction consistency score: 8.7, Coverage: 21
ORGANISM(S): 10090 
2019-00-00 | 386924191 | PAXDB
ProteomicsM.musculus - Lung, iBAQ (Angelidisetal,natcommun.2019)
abundance based on iBAQ, Interaction consistency score: 9.7, Coverage: 21
ORGANISM(S): 10090 
2019-00-00 | 3284560666 | PAXDB
UnknownBurden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990-2023: a systematic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12535840 | biostudies-literature
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