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ProteomicsMeasuring glycolytic flux in single yeast cells with an orthogonal synthetic biosensor
Metabolic heterogeneity modulates productivity, antibiotic resistance and cancer aggressiveness. Since metabolic fluxes represent the functional output of metabolism, with glycolytic flux correlating with highly-productive phenotypes and cancer, such flux map will be indicative of the cellular metab...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-12-17 | PXD012964 | Pride
Yeast Mcherry Cggr 
ProteomicsAbsolute Quantification of 10 Centrosomal Proteins
Centrioles are essential for the formation of centrosomes and cilia. While numerical and/or structural centrosomes aberrations are implicated in cancer, mutations in centriolar and centrosomal proteins are genetically linked to ciliopathies, microcephaly and dwarfism. The evolutionarily conserved me...
ORGANISM(S): Homo sapiens (Human) 
2016-07-22 | PXD003927 | Pride
Srm Centrosome Absolute quantification Mass spectrometry 
ProteomicsProteomics analysis of 3 months induced RAmKO mice muscle
Maintaining skeletal muscle mass is of high importance as muscle atrophy like during sarcopenia or cachexia lead to a decrease in independence and a higher risk of morbidity and mortality. A leading compound in the treatment against ageing and cancer is rapamycin, an inhibitor of mechanistic target ...
ORGANISM(S): Mus musculus (Mouse) 
2019-10-14 | PXD013294 | Pride
Mus musculus Mtorc1 Rapamycin Muscle 
ProteomicsProtein abundance comparison of human cells infected with Shigella flexneri over different time periods
The enteroinvasive bacterium Shigella flexneri invades the intestinal epithelium of humans. During infection, several injected effector proteins promote bacterial internalization, and interfere with multiple host cell responses. To obtain a systems-level overview of host signaling during infection, ...
ORGANISM(S): Homo sapiens (Human) 
2017-01-23 | PXD000219 | Pride
Infection Phosphoproteomics S. flexneri 
UnknownMulti-faceted examination of a deepwater seamount reveals ecological patterns among coral and sponge communities in the equatorial Pacific.
Not available
S-EPMC11742039 | biostudies-literature
ProteomicsAnalysis of centrosomal protein
Shotgun proteomics and targeted analysis of centrosomal duplication factors controlled by SCF E3 ubiquitin ligases
ORGANISM(S): Homo sapiens (Human) 
2018-01-22 | PXD008272 | Pride
Phosphorylation Centrosome Stil 
ProteomicsAnalysis of ablation of mitochondrial fission in adult forebrain neurons
Well-balanced mitochondrial fission and fusion processes are essential for nervous system development. Loss of function of the main mitochondrial fission mediator, dynamin-related protein 1 (Drp1), is lethal early during embryonic development or around birth, but the role of mitochondrial fission in...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-25 | PXD004890 | Pride
Neurons Synaptic dysfunction Tmt Lc-ms/ms 
ProteomicsDual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis
Muscle size is controlled by the PI3K-PKB/Akt-mTORC1-FoxO pathway, which integrates signals from growth factors, energy and amino acids to activate protein synthesis and inhibit protein breakdown. While mTORC1 activity is necessary for PKB/Akt-induced muscle hypertrophy, its constant activation alon...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-28 | PXD034117 | Pride
Tmt Lc-ms Mtor Muscle 
UnknownFrequent occurrence of therapeutically reversible CMV-associated encephalopathy during radiotherapy of the brain.
Not available
S-EPMC5793811 | biostudies-literature
UnknownA Modular Approach to Asymmetric Mg(I) Complexes Using a Unique Cyclopentadienyl Mg(I) Complex.
Not available
S-EPMC12684354 | biostudies-literature
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