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TranscriptomicsTranscription profiling of CD8+ T cells from BM3.3 transgenic mice during responses to TCR ligands of different avidity
To identify the molecular bases for divergence in differentiation programs of naïve CD8 T cells, we monitored gene expression profile of CD8+ T cells from BM3.3 transgenic mice during responses to TCR ligands of different avidity (full response with antigen presenting cells from C57BL/6 mice , parti...
ORGANISM(S): Mus musculus 
2004-07-07 | E-MEXP-16 | biostudies-arrayexpress
MetabolomicsComparison of lipidome profiles of Caenorhabditis elegans—results from an inter-laboratory ring trial

Introduction

Lipidomic profiling allows 100s if not 1000s of lipids in a sample to be detected and quantified. Modern lipidomics techniques are ultra-sensitive assays that enable the discovery of novel biomarkers in a variety of fields and provide new insight in mechanistic investigations. D...
2022-02-21 | MTBLS2016 | MetaboLights
ProteomicsProteome of group 2 innate lymphoid cells (ILC2s) stimulated with IL33 and TL1A
We analyzed the total proteome of group 2 innate lymphoid cells (ILC2s) after different stimulation with interleukin-33 (IL-33), a cytokine playing a critical role in human asthma, and TL1A, a TNF-family cytokine also known to activate ILC2s. Upon combined stimulation with IL-33 plus TL1A, we show t...
ORGANISM(S): Mus musculus (Mouse) 
2024-03-05 | PXD041987 | Pride
Tl1a Cytokine Il33 Group 2 innate lymphoid cells Ilc2 Whole cell lysate Allergic inflammation Type 2 response Proteome Alarmin 
TranscriptomicsImmunosuppressive capabilities of mesenchymal stromal cells are maintained under hypoxic growth conditions and after gamma irradiation
To investigate factors that might influence the T-cell suppressive capabilities of mesenchymal stroma cells, T-cell suppressive and non-suppressive mesenchymal stroma cells were compared. Immunosuppressive capabilities of MSCs was determined via T-cell proliferation assay.
ORGANISM(S): Homo sapiens 
2015-01-20 | E-MTAB-2396 | biostudies-arrayexpress
UnknownA New Option for Pain Prevention Using a Therapeutic Virtual Reality Solution for Bone Marrow Biopsy (REVEH Trial): Open-Label, Randomized, Multicenter, Phase 3 Study.
Not available
S-EPMC9978987 | biostudies-literature
TranscriptomicsTranscription profiling of human childhood B-lineage ALL patients reveals five distinct biological processes and 14 differentially expressed genes characterize TEL/AML1-positive leukemia
Background; The t(12;21)(p13;q22) translocation is found in 20 to 25% of cases of childhood B-lineage acute lymphoblastic leukemia (B-ALL). This rearrangement results in the fusion of ETV6 (TEL) and RUNX1 (AML1) genes and defines a relatively uniform category, although only some patients suffer very...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9170 | biostudies-arrayexpress
GenomicsActive STAT5 in CD8 T cells imprints a T-Bet-dependent Tc-1 program with repressed IL-6/ TGFb1 signaling leading to enhanced anti-tumor responses
CD8 T cells (TCs) expressing active STAT5 (STAT5CA) transcription factors were found to be superior to un-manipulated counterparts in their long-term persistence, capacity to infiltrate a tumor, thrive in its microenvironment and induce its regression. STAT5CA induced sustained expression of genes c...
ORGANISM(S): Mus musculus 
2013-09-13 | E-GEOD-41818 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse CD8 T cells in response to P1A antigen expressing tumor cells or cells not expressing 1A antigen
Activation status of CD8 T cells in response to a tumor challenge. Although both natural killer (NK) cells and CD8 T cells are capable of anti-tumor responses, Recombinase Activating Gene (RAG)-deficient mice, which have a normal component of NK cells, are incapable of rejecting the P815 mastocytoma...
ORGANISM(S): Mus musculus 
2007-12-01 | E-MEXP-1285 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse NK cells in presence/absence of activated CD8 T cells
we compare NK cells in presence of activated CD8 T cells or not. Although both natural killer (NK) cells and CD8 T cells are capable of anti-tumor responses, Recombinase Activating Gene (RAG)-deficient mice, which have a normal component of NK cells, are incapable of rejecting the P815 mastocytoma t...
ORGANISM(S): Mus musculus 
2007-11-01 | E-MEXP-1284 | biostudies-arrayexpress
TranscriptomicsGene expression profile analysis of inducible melanotic and amelanotic melanoma in mice
We analyzed an inducible melanoma model in TiRP Ink4a/ArfF/F B10.D2 mice based on the conditional deletion in melanocytes of two tumor suppressor genes INK4a/Arf coupled to the expression of the oncogene H-rasG12V and a known tumor antigen (Hujibers et al. Cancer Res. 66:3278,2006; Soudja et al. Can...
ORGANISM(S): Mus musculus 
2013-06-26 | E-GEOD-29304 | biostudies-arrayexpress
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