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ProteomicsA metabolic map of the DNA damage response identifies PRDX1 in nuclear ROS scavenging and aspartate synthesis
While cellular metabolism impacts the DNA damage response, a systematic understanding of the metabolic requirements that are crucial for DNA damage repair has yet to be achieved. Here, we investigate the metabolic enzymes and processes that are essential when cells are exposed to DNA damage. By inte...
ORGANISM(S): Homo sapiens (Human) 
2023-03-31 | PXD035532 | Pride
Dna damage response  peroxiredoxin 1  reactive oxygen species scavenging  electron transport chain  chromatin  aspartate metabolism 
ProteomicsMitochondrial fuels ATP in the nucleus to prevent cell cycle arrest during mechanical confinement
Abstract The physical microenvironment regulates cell behaviour during tissue development and disease. Whether mechanical stress and physical space constraints reshape the subcellular localization of organelles and proteins resulting in functional adaptations is, however, unknown. Here, we performed...
ORGANISM(S): Homo sapiens (Human) 
2025-06-12 | PXD043524 | Pride
Confinement Nuclear atp Mitochondria Cell cycle Nucleus Dna damage 
ProteomicsChromatin cell cycle proteomics reveals nuclear metabolism
The progression of the cell cycle is regulated by the expression of specific genes and fluctuations in cellular metabolic states. By conducting cell cycle-based transcriptomics, proteomics, and metabolomics analyses, previous research has identified cell cycle-dependent alterations at the molecular,...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD055357 | Pride
Metabolism Cell cycle Chromatin Enzymes 
ProteomicsComprehensive chromatome profiling identifies metabolic enzymes on chromatin in healthy and cancer cells
we have performed a subcellular fractionation protocol, which enriches the chromatin-bound proteins across a panel of tissue types, both for cancerous and untransformed cells. Indeed we identify both metabolic enzymes which are consistently moonlighting on chromatin, while others are tissue and canc...
ORGANISM(S): Homo sapiens (Human) 
2025-11-13 | PXD047504 | Pride
Chromatome  cancer  chromatin 
TranscriptomicsNOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation
Breast cancer is genetically heterogeneous, and recent studies have underlined a prominent contribution of epigenetics to the development of this disease. To uncover new synthetic lethalities with known breast cancer oncogenes, we screened an epigenome-focused short hairpin RNA library on a panel...
ORGANISM(S): Homo sapiens 
2014-11-21 | E-GEOD-61727 | biostudies-arrayexpress
UnknownDYNLL/LC8 protein controls signal transduction through the Nek9/Nek6 signaling module by regulating Nek6 binding to Nek9.
Not available
S-EPMC3093884 | biostudies-literature
Unknownhu.MAP3.0: Atlas of human protein complexes by integration of > 25,000 proteomic experiments.
Not available
S-EPMC11507723 | biostudies-literature
Unknownhu.MAP3.0: atlas of human protein complexes by integration of >25,000 proteomic experiments.
Not available
S-EPMC12222714 | biostudies-literature
UnknownThe TP53-activated E3 ligase RNF144B is a tumour suppressor that prevents genomic instability.
Not available
S-EPMC11057071 | biostudies-literature
UnknownCell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states.
Not available
S-EPMC7612075 | biostudies-literature
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