Secreted proteome

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Proteomics (1080)
Unknown (775)
Genomics (63)
Transcriptomics (45)
Metabolomics (13)
Other (9)
Multiomics (1)

Organisms

Homo sapiens (51)
Mus musculus (24)
Yersinia pestis CO92 (7)
Rattus norvegicus (4)
Canis lupus familiaris (3)
Macaca fascicularis (3)
synthetic construct (3)
Pectobacterium carotovorum (2)
Xenopus laevis (2)
Streptomyces sp. SirexAA-E (1)
Streptomyces griseus subsp. griseus NBRC 13350 (1)
Aspergillus niger (1)
Streptomyces lividans (1)
Bartonella henselae (1)
Pseudomonas aeruginosa PAO1 (1)
Plasmodium falciparum (1)
Actinoplanes sp. SE50/110 (1)
Saccharomyces cerevisiae (1)
Danio rerio (1)
Agrobacterium fabrum (1)
rat gut metagenome (1)
Caulobacter vibrioides NA1000 (1)
Perna viridis (1)
Pectobacterium atrosepticum (1)
other sequences (1)
Porphyromonas gingivalis (1)
Caulobacter vibrioides (1)
Caenorhabditis elegans (1)
Bos taurus (1)
Sus scrofa (1)

Organisms

Homo sapiens (22)
Mus musculus (4)
Oryza sativa Japonica Group (2)
Pectobacterium carotovorum (1)
Porphyromonas gingivalis (1)
Agrobacterium fabrum (1)
Caulobacter vibrioides (1)
Perna viridis (1)
Caulobacter vibrioides NA1000 (1)
rat gut metagenome (1)
pig gut metagenome (1)
Xenopus laevis (1)
Ovis aries (1)
Bos taurus (1)

Repository

pride (895)
MassIVE (85)
ENA (56)
iProX (41)
geo (38)
PAXDB (26)
biostudies-arrayexpress (18)
jPOST (18)
MetaboLights (10)
GPMDB (7)
PanoramaPublic (7)
PeptideAtlas (6)
GNPS (3)

Tissue

Cell culture (186)
Epithelial cell (61)
Fibroblast (33)
Macrophage (33)
Brain (30)
Blood plasma (24)
Liver (19)
Saliva (19)
Cell suspension culture (18)
Blood (17)
Skin (17)
Bone marrow (16)
Stem cell (16)
Lung (15)
Permanent cell line cell (15)
Plant cell (15)
Whole body (15)
Colon (13)
Blood serum (12)
Hepatocyte (12)
Heart (11)
Endothelial cell of umbilical vein (10)
Leaf (10)
Extracellular vesicle (9)
Primary cell (9)
T cell (9)
B cell (8)
Blood cell (8)
Pancreas (8)
Umbilical vein (8)

Disease

Breast cancer (25)
Disease free (19)
Tuberculosis (14)
Colon cancer (11)
Glioblastoma (10)
Not Available (7)
Wounds and Injuries (7)
Cardiovascular system disease (6)
Acute leukemia (5)
Alzheimer's disease (5)
Human immunodeficiency virus infectious disease (5)
Cervix carcinoma (4)
Diphtheria (4)
Osteoarthritis (4)
Toxoplasmosis (4)
Amyotrophic lateral sclerosis (3)
Brain cancer (3)
Lymphoma (3)
Malignant pleural mesothelioma (3)
Melanoma (3)
Pancreatic cancer (3)
Pancreatic ductal adenocarcinoma (3)
Prostate adenocarcinoma (3)
Pulmonary tuberculosis (3)
Type 2 diabetes mellitus (3)
Atherosclerosis (2)
Chronic kidney disease (2)
Cryptosporidiosis (2)
Fungal infectious disease (2)
Obesity (2)

Technology Type

Mass Spectrometry (895)
Shotgun proteomics (570)
Bottom-up proteomics (154)
Data-dependent acquisition (76)
Gel-based experiment (73)
Affinity purification coupled with mass spectrometry proteomics (47)
Data-independent acquisition (33)
Top-down proteomics (32)
SWATH MS (20)
Mass spectrometry (9)
HDMSE (7)
SRM/MRM (6)
All-ion fragmentation (5)
Chemical cross-linking coupled with mass spectrometry proteomics (4)
Mass spectrometry imaging (2)
Mass spectrometry assay (1)
Affinity proteomics (1)
MSE (1)
Proteogenomics (1)
SomaScan affinity proteomics (1)

Instrument Platform

Q Exactive (45)
Instrument (7)
Orbitrap Fusion Lumos (6)
Orbitrap Fusion (5)
LTQ Orbitrap Velos (5)
LTQ FT (5)
Q Exactive HF (4)
Illumina MiSeq (3)
Orbitrap Exploris 480 (3)
Q Exactive Plus (3)
LTQ Orbitrap (2)
LTQ Orbitrap Elite (2)
Q Exactive HF-X (2)
Illumina HiSeq 1000 (1)
Illumina NovaSeq 6000 (1)
Autoflex II (1)
LC/MS/MS (1)
LTQ (1)
LTQ (Thermo Scientific instrument model) (1)
LTQ Orbitrap Discovery (1)
LTQ XL (1)
LTQ XL ETD (1)
Orbitrap Eclipse (1)
Orbitrap Fusion ETD (1)
Q-Exactive (Thermo Fisher) (1)
Synapt G2 HDMS (1)
TSQ Vantage (1)
TimsTOF Pro (1)
TimsTOF Ultra (1)
TimsTOF fleX (1)

Publication Date

2022 (145)
2023 (129)
2021 (123)
2025 (115)
2024 (92)
2020 (90)
2026 (88)
2016 (78)
2018 (70)
2019 (70)
2017 (46)
2015 (28)
2014 (14)
2013 (10)
2012 (8)
2010 (4)
2011 (1)
2007 (1)
2006 (1)
2008 (1)
2005 (1)

UNIPROT ID/AC

1433B_HUMAN (18)
1433E_HUMAN (18)
1433G_HUMAN (18)
1433Z_HUMAN (18)
4F2_HUMAN (18)
6PGD_HUMAN (18)
6PGL_HUMAN (18)
A1AG1_HUMAN (18)
A1AG2_HUMAN (18)
A1AT_HUMAN (18)
A1BG_HUMAN (18)
A2AP_HUMAN (18)
A2GL_HUMAN (18)
A2MG_HUMAN (18)
AACT_HUMAN (18)
ACTN1_HUMAN (18)
ACTN4_HUMAN (18)
ACTS_HUMAN (18)
ADA2_HUMAN (18)
ADIPO_HUMAN (18)
AFAM_HUMAN (18)
AIFM1_HUMAN (18)
AKAP1_HUMAN (18)
ALBU_HUMAN (18)
ALDOA_HUMAN (18)
ALDOB_HUMAN (18)
AMBP_HUMAN (18)
AMPB_HUMAN (18)
AMPE_HUMAN (18)
AMPN_HUMAN (18)

CHEBI ID

CHEBI:16750 (3)
CHEBI:17596 (3)
CHEBI:9380 (2)
CHEBI:3110 (2)
CHEBI:28998 (2)
CHEBI:80538 (2)
CHEBI:28330 (2)
CHEBI:19092 (2)
CHEBI:43474 (2)
CHEBI:36090 (2)
CHEBI:61316 (2)
CHEBI:28724 (2)
CHEBI:15414 (2)
CHEBI:17154 (2)
CHEBI:16040 (2)
CHEBI:16467 (2)
CHEBI:80537 (2)
CHEBI:28635 (2)
CHEBI:22652 (2)
CHEBI:28918 (2)
CHEBI:15891 (2)
CHEBI:17748 (2)
CHEBI:17256 (2)
CHEBI:16335 (2)
CHEBI:29045 (2)
CHEBI:7916 (2)
CHEBI:28867 (2)
CHEBI:30797 (2)
CHEBI:16708 (2)
CHEBI:17568 (2)

Metabolite Name

Cytosine (3)
Adenosine (3)
Biotinyl-5'-AMP (2)
(10S)-Juvenile hormone III acid diol (2)
Orthophosphate (2)
Istamycin C1 (2)
Accurate mass (2)
Syringin (2)
1-Pyrroline (2)
Leucine (2)
Glutarylcarnitine (2)
Maleamate (2)
L-Pipecolic acid (2)
Alanine (2)
4-Hydroxy-L-threonine (2)
Sulfate (2)
Aprobarbital (2)
Tiglylcarnitine (2)
(10S)-Juvenile hormone III diol (2)
5'-Methylthioadenosine (2)
Citrulline (2)
L-Arginine (2)
Deoxyadenosine (2)
Pantothenic acid (2)
Taurine (2)
Histamine (2)
Arginine (2)
Proline (2)
Phenylalanine (2)
Adenine (2)

First Public Date

2022 (11)
2020 (11)
2024 (8)
2026 (5)
2025 (5)
2023 (5)
2021 (3)
2016 (3)
2019 (1)
2018 (1)
2015 (1)
2014 (1)
2013 (1)

Classification

bacteria (2)

Modification

15.994915 (3)
4x(15)N labeled L-arginine (3)
2x(15)N labeled L-lysine (2)
4-tetrahydrothiazine-3-carboxylic acid (2)
4x(2)H labeled dimethylated residue (2)
57.021464 (2)
Not available (2)
4 (1)
N6-dimethyl-L-lysine (1)

Study type

Transcription profiling by array (8)
RNA-seq of coding RNA (7)
Transcription profiling by SAGE (1)
MicroRNA profiling by high-throughput sequencing (1)
Proteomic profiling by array (1)

Release Date

2022 (77)
2020 (68)
2023 (62)
2025 (58)
2021 (58)
2024 (56)
2018 (53)
2019 (51)
2016 (41)
2015 (40)
2014 (40)
2017 (37)
2013 (29)
2010 (22)
2011 (20)
2012 (20)
2009 (19)
2008 (15)
2026 (8)
2006 (7)
2007 (6)
2005 (3)
2004 (2)
2002 (1)

Lab affiliation

University of Vienna, Faculty of Chemistry, Department of Analytical Chemistry (34)
Head of the Curie Institute Mass Spectrometry Platform (6)
Amsterdam UMC, Vrije Universiteit Amsterdam, Medical Oncology, Cancer Center Amsterdam, OncoProteomics Laboratory, Amsterdam, Netherlands (4)
Mass Spectrometry Facility, Department of Chemistry and Biochemistry, San Francisco State University, USA (4)
OncoProteomics Laboratory, Dept of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands (4)
The University of Melbourne (4)
UMR 7367 CNRS-UL IMoPA Biopôle de l'Université de Lorraine Campus Brabois-Santé 9 avenue de la forêt de Haye 54505 Vandoeuvre-les-Nancy FRANCE (4)
CRUK Beatson Institute (3)
Division of Genetic and Genomic Medicine, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, USA (3)
Fondazione Ri.MED (3)
Fourth Hospital of Hebei Medical University (3)
Functional Genomics, University Medicine Greifswald, Germany (3)
University of Greifswald, Institute of Microbiology, Department of Microbial Proteomics, Greifswald, Germany (3)
1VIB-UGent Center for Medical Biotechnology, VIB, 9052 Ghent, Belgium 2Department of Biomolecular Medicine, Ghent University, 9052 Ghent, Belgium (2)
Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, CB2 0XY, UK (2)
Charles Perkins Centre, School of Medical Sciences, University of Sydney, Sydney, Australia. (2)
College of Plant Protection, Northwest A&F University (2)
Copenhagen Center for Glycomics, Department of Cellular and Molecular Medicine, University of Copenhagen (2)
Department Biologie Professur für Mikrobiologie (2)
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", Caserta, Italy (2)
Department of Microbial Proteomics, Institute of Microbiology, University of Greifswald, Greifswald, Germany (2)
Department of Microbiology and Immunology, Lab of Molecular Bacteriology, Rega Institute, KU Leuven (2)
Department of Molecular Microbiology, Washington University School of Medicine, 4940 Parkview Place, Campus Box 8230, St. Louis, MO 63110, USA (2)
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute, Jena, Germany (2)
Departments of Biomedical Sciences, Seoul National University, Seoul, Korea (2)
Departments of Pharmacology & Experimental Therapeutics and Neurology Boston University School of Medicine (2)
Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town (2)
FBI (2)
Faculty of Chemistry, Biotechnology and Food Science Norwegian University of Life Sciences (2)
Faculty of Chemistry, Biotechnology and Food Science Norwegian University of Life Sciences Post Office Box 5003 1432, Ås Norway (2)

Tags

pathogen (2)
pathogen:bacterium (2)

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Bioaccumulation of therapeutic drugs by human gut bacteria: secreted metabolite analysis (FIA-MS) (C.saccharolyticum;E.coli;L.plantarum;L.lactis;S.salivarius assays)

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. Interactions at this level have only recently started to being systematically mapped and the main underlying mechanism proposed is chemical transformation of drugs by microbes (biotransformation). Here, we invest...

2021-07-20 | MTBLS1791 | MetaboLights

Bioaccumulation of therapeutic drugs by human gut bacteria: secreted metabolite analysis for resting cells (B.uniformis;C.saccharolyticum assays)

2021-07-20 | MTBLS1757 | MetaboLights

DsbA plays a critical and multi-faceted role in the production of secreted virulence factors by Erwinia carotovora

Erwinia carotovora subsp. atroseptica (Eca) is an enterobacterial phytopathogen causing economically-significant soft rot disease. Pathogenesis is mediated by multiple secreted virulence factors, many of which are secreted by the Type II (Out) secretion system. DsbA catalyses the introduction of dis...

ORGANISM(S): Pectobacterium carotovorum

2010-06-20 | E-GEOD-10647 | biostudies-arrayexpress

SILAC proteomic analysis of secreted proteins from PLC cells expressing EV or PRSS35

Since PRSS35 only exhibited tumor suppressive effects in mice, but not in the cultured cells, we speculated that some factors in the microenvironment are affected by PRSS35. To explore this possibility, we performed SILAC proteomic analysis in conjunction with RNA sequencing to identify secreted pro...

ORGANISM(S): Homo sapiens (Human)

2023-02-15 | PXD033579 | Pride