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ProteomicsAML patients samples compared to Healthy Human CD34+ cells (LFQ LC-MSMS)
Cryopreserved normal CD34 + bone marrow cells were derived from eight healthy Caucasians (four men and four women; PromoCell GMBH; Heidelberg, Germany), and their age did not differ significantly from the AML patients analysed in the study. The submitted samples have been analyzed together with raw ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD058846 | Pride
Aml Lfq Lc-ms/ms 
ProteomicsPreservation methods and PBS washing affect the AML proteome
In the current study, we have studied the effect of three storage and preparation protocols on two AML-derived cell lines: 1) cryopreservation of viable cells for storage in liquid nitrogen, 2) cell pellet storage in liquid nitrogen and 3) freshly SDS lysed cell lysate stored at -°80. We further stu...
ORGANISM(S): Homo sapiens (Human) 
2018-01-19 | PXD008361 | Pride
Aml Dmso Pbs Storage conditions 
ProteomicsSERUM_Protein expression profiling of serum and lungs at different stages of metastatic development in a human triple negative breast cancer xenograft model - Part 2
The main objective of this study was to evaluate the protein expression profiling of serum and lungs at different stages of metastatic development in a human triple negative MDA-MB
ORGANISM(S): Mus musculus (Mouse) 
2019-05-07 | PXD010249 | Pride
Breast cancer Serum Lcms 
ProteomicsProtein expression profiling of serum and lungs at different stages of metastatic development in a human triple negative breast cancer xenograft model - Part 1
The main objective of this study was to evaluate the protein expression profiling of serum and lungs at different stages of metastatic development in a human triple negative MDA-MB
ORGANISM(S): Mus musculus (Mouse) 
2019-05-07 | PXD010248 | Pride
Lung Plasma Mice Lcms 
ProteomicsPlasma Mouse LC-MSMS - Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival
Patients diagnosed with glioblastoma (GBM) with sustained synthesis of the DNA repair enzyme, O6-methyl guanine DNA methytransferase (MGMT), are rendered resistant to Temozolomide (TMZ) chemotherapy. Here, we hypothesized that pretreatment with the proteasome inhibitor Bortezomib (BTZ, Velcade) migh...
ORGANISM(S): Mus musculus (Mouse) 
2019-08-20 | PXD007193 | Pride
Glioblastoma Plasma Mouse Autophagy 
ProteomicsEPAC1 knockout mouse effects in platelets and plasma
ABSTRACT FOR BOTH PLASMA AND PLATELET-LYSATE In this article we describe the involvement of exchange factor activated by cAMP 1 (Epac1) in hemostasis and platelet activation. We have used plasma and platelet-lysate from EPAC1 knockout mice and wild-type control mice in label-free proteomics with an ...
ORGANISM(S): Mus musculus (Mouse) 
2017-07-25 | PXD000282 | Pride
Epac1 knockout Platelets Lc-ms Plasma Label-free 
ProteomicsHigh and low risk of adverse acute myeloid leukemia (AML)
LC-MS/MS raw files of proteomics, phosphoproteomics and pTyr-proteomics from patients with high and low risk of adverse AML
ORGANISM(S): Homo sapiens (Human) 
2021-01-04 | PXD019785 | Pride
Acute myeloid leukemia risk 
Proteomics7 paired AML Diagnosis vs Relapse patient samples
MS-based proteomics and phosphoproteomics study based on 7 paired diagnosis-first relapse AML patient samples
ORGANISM(S): Homo sapiens (Human) 
2020-06-12 | PXD018359 | Pride
Acute myeloid leukemia relapase 
ProteomicsHuman AML patient samples, Method Optimization, LC-MSMS
We evaluated different in-solution and filter-aided sample preparation (FASP) proteomic workflows, and different enrichment strategies of phosphorylated peptides on acute myeloid leukemia (AML) patient samples. We also studied the effect of liquid nitrogen storage on the proteome and phosphoproteome...
ORGANISM(S): Homo sapiens (Human) 
2016-04-26 | PXD003822 | Pride
Human Lc-msms Aml cells Super-silac Label-free Sample preparation Phosphopeptide enrichment Ltq-orbitrap elite 
ProteomicsHuman AML cell lines LC-MS/MS - Performance of Super-SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines
As a direct consequence of the high diversity of the aggressive blood cancer acute myeloid leukemia (AML), proteomic samples from patients are strongly heterogeneous, rendering their accurate relative quantification challenging. In the present study, we investigated the benefits of using a super-SI...
ORGANISM(S): Homo sapiens (Human) 
2014-07-15 | PXD000441 | Pride
Human Orbitrap velos pro Lc-ms Cell lines Super-silac Aml 
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