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ProteomicsProteomics of serotonergic autoregulation
Serotonin regulates its own production, degradation and release in the Raphe nuclei of the brain mainly by modifying the level and activity of autoreceptors on serotonin-producing neurons, such as 5-HT1A and 5-HT1B. This autoregulation is probably the reason for the delayed response of patients with...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055579 | Pride
Serotonin Serotonin transporter Brain Tryptophan hydroxylase Autoregulation Mouse 
ProteomicsHyperactive Mouse Serotonin Transporter Interacting Proteins LC-MSMS
The serotonin (5-HT) transporter (SERT) is a key determinant of the concentration of 5-HT available for synaptic signaling and is the target of the antidepressant-selective 5-HT reuptake inhibitors (SSRIs). In addition to the role of SERT in mediating the actions of antidepressant medications, multi...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-29 | PXD018695 | Pride
Lc-msms Mouse Serotonin transporter interacting proteins Midbrain 
ProteomicsConformational dynamics of the human serotonin transporter during substrate and drug binding
The serotonin transporter (SERT), a member of the neurotransmitter:sodium symporter family, is responsible for termination of serotonergic signaling by re-uptake of serotonin (5-HT) into the presynaptic neuron. Its key role in synaptic transmission makes it a major drug target, e.g. for the treatmen...
ORGANISM(S): Homo sapiens (Human) 
2019-05-15 | PXD013750 | Pride
Hdx-ms  protein-ligand interactions  membrane proteins  mass spectrometry 
GenomicsThe serotonin transporter is a regulator of neurodegeneration and axon regeneration after retinal injury
The serotonin transporter is a regulator of neurodegeneration and axon regeneration after retinal injury
PRJNA644185 | ENA
TranscriptomicsGene x environment effect of serotonin transporter genotype and acute stressor on amygdala gene expression
The amygdala is a prominent region of the brain processing stress-related emotion and vigilance. Additionally it is known that the serotonergic system is strongly involved in stress response and adaptation. The serotonin transporter (5-HTT) as key regulator of serotonergic activity in the brain is a...
ORGANISM(S): Mus musculus 
2013-03-13 | E-GEOD-40393 | biostudies-arrayexpress
GenomicsSerotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome [RNA-seq]
Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome [RNA-seq]
PRJNA1033602 | ENA
GenomicsSerotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome [ChIP-seq]
Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome [ChIP-seq]
PRJNA1033600 | ENA
ProteomicsThe dopamine transporter antiports potassium to increase the uptake of dopamine
The dopamine transporter facilitates dopamine reuptake from the extracellular space to terminate neurotransmission. The transporter belongs to the neurotransmitter:sodium symporter family, which includes transporters for serotonin, norepinephrine, and GABA that utilize the Na+ gradient to drive the ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2022-05-20 | PXD032663 | Pride
Ms  membrane proteins  mass spectroemetry  hydrogen-deuterium exchange  transporter 
GenomicsSequencing_emsert
Sequencing of the Echinococcus multilocularis serotonin transporter gene
PRJEB22753 | ENA
GenomicsDisruption of the Placenta-Brain Axis in Transgenic Mice Lacking Serotonin Transporter (SERT) in Trophoblast Cell
Disruption of the Placenta-Brain Axis in Transgenic Mice Lacking Serotonin Transporter (SERT) in Trophoblast Cell
PRJNA1300422 | ENA
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