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ProteomicsStructural and proteomic repercussions of growth hormone receptor deficiency on the pituitary gland – lessons from a translational pig model
Growth hormone receptor deficiency (GHRD) results in low serum insulin-like growth factor 1 but high, non-functional GH levels. This study investigates the histomorphological and molecular alterations associated with GHRD. Pituitary glands from 6 months old GHR-KO pigs and control animals were compa...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-05-12 | PXD035833 | Pride
Proteomics Brain Growth hormone receptor deficiency Pig Animal model 
ProteomicsRepeated bisphenol A exposure in low concentrations alters the functionality and environment of a human induced pluripotent stem cell-derived cardiomyocyte model
Early embryonic development represents a sensitive time-window during which the foetus might be highly vulnerable to the exposure of environmental contaminants, potentially leading to heart diseases also later in life (Developmental Origins of Health and Disease (DOHaD) concept). Bisphenol A (BPA), ...
ORGANISM(S): Homo sapiens (Human) 
2023-08-15 | PXD042046 | Pride
Bisphenol a (bpa) Proteomics Dohad Extracellular matrix remodelling Human induced pluripotent stem cell-derived cardiomyocytes (hipsc-cms) New approach methodologies (nams) 
ProteomicsThe assessment of hiPSC-derived Neural Stem Cells after a repeated-dose bisphenol A exposure
The present study evaluated the effects of a repeated-dose exposure of environmentally relevant BPA concentrations during the in vitro 3D neural induction of human induced pluripotent stem cells (hiPSCs), emulating a chronic exposure scenario. Quantitative proteomics at D21 revealed several differen...
ORGANISM(S): Homo sapiens (Human) 
2023-09-06 | PXD042045 | Pride
Bisphenol a Neural stem cells Dohad New approach methodology Human-induced pluripotent stem cells 
ProteomicsProteomics and Metabolomics based analysis of Metabolic changes in a swine model of Pulmonary Hypertension
Pulmonary vein stenosis (PVS) is a rare type of Pulmonary Hypertension (PH), which impacts the flow and pressure within the lung tissue and vasculature resulting in endothelial dysfunction and metabolic changes. We used a pig model in order to mimic PH post PVS using pulmonary vein banding (PVB) of ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-04-20 | PXD038982 | Pride
Proteomics Metabolomics Pulmonary hypertension Pig model 
ProteomicsMulti-omics profiling of lung samples from genetically diabetic pigs reveals reduced ALOX15 expression and impaired eicosanoid switching as mechanisms contributing to a proinflammatory milieu
To evaluate molecular consequences of insulin-deficient diabetes mellitus for lung tissue, we used clinically diabetic pig model of mutant INS gene induced diabetes of youth (MIDY). A multi-omics analysis combining in-depth data-independent acquisition proteomics, and targeted lipidomics revealed mu...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-07-01 | PXD038014 | Pride
Lipoxygenase Lung Lipidome Diabetes Biobank Insulin deficiency Pig model Proteome 
ProteomicsMaternal hyperglycemia induces alterations in hepatic amino acid, glucose and lipid metabolism of neonatal offspring: Multi-omics insights from a diabetic pig model
Intrauterine exposure to disturbed maternal glucose metabolism is associated with adverse consequences for the offspring. Hepatic disorders in affected offspring emerge in early development; thus, detection of disease biomarkers at an early stage may elucidate the underlying mechanisms of maternal h...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-07-10 | PXD040305 | Pride
Maternal diabetes Proteomics Metabolomics Liver Protein-protein interaction Clinical parameters Pig model Neonates 
ProteomicsSystemic deletion of DMD exon 51 rescues clinically severe Duchenne muscular dystrophy in a pig model lacking DMD exon 52
Duchenne muscular dystrophy (DMD) is a fatal X-linked disease caused by mutations in the dystrophin (DMD) gene, leading to the complete absence of DMD and progressive degeneration of skeletal and heart muscles. Expression of an internally shortened dystrophin in DMD subjects (DMDΔ52) can be achieved...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-07-11 | PXD039533 | Pride
Becker muscular dystrophy Proteomics Duchenne muscular dystrophy Pig model 
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