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ProteomicsProteomic analysis of FPA interactors
Genes involved in disease resistance are some of the fastest evolving and most diverse components of genomes. Large numbers of nucleotide-binding, leucine-rich repeat receptor genes (NLRs) are found in plant genomes and provide disease resistance. However, NLRs can trigger autoimmunity, disrupt bene...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2020-12-16 | PXD022684 | Pride
Transcription Arabidopsis Fpa Rna processing 
UnknownR othia mucilaginosa is an anti-inflammatory bacterium in the respiratory tract of patients with chronic lung disease.
Not available
S-EPMC9068977 | biostudies-literature
ProteomicsDeciphering Differential Gut Bacterial Drug Metabolism with Activity-Based Protein Profiling
Gut bacterial β-glucuronidases (GUS) promote the toxic side effects of therapeutics by reactivating drugs from their inactive glucuronide conjugates. It is increasingly clear that the interindividual variability of bacterial GUS-producing species in the gut microbiota contributes to differential dru...
ORGANISM(S): human gut metagenome 
2019-12-03 | PXD014864 | Pride
Drug metabolism Gut microbiome Activity-based protein profiling 
TranscriptomicsExpression data from Ts1Cje and disomic C57BL/6 adult neurospheres
Down syndrome is the most common form of genetic mental retardation. How Trisomy 21 causes mental retardation remains unclear and its effects on adult neurogenesis have not been addressed. To gain insight into the mechanisms causing mental retardation we used microarrays to investigate gene expressi...
ORGANISM(S): Mus musculus 
2010-07-16 | E-GEOD-17760 | biostudies-arrayexpress
GenomicsLarge-Scale Discovery of Enhancers from Human Heart Tissue
Development and function of the human heart depend on the dynamic control of tissue-specific gene expression by distant-acting transcriptional enhancers. While large numbers of heart enhancers have been identified using the mouse as a model system, many of these regulatory sequences are poorly cons...
ORGANISM(S): Mus musculus 
2011-12-04 | E-GEOD-32587 | biostudies-arrayexpress
ProteomicsKinase Selectivity Profiling of anti-MRSA Diarylimidazoles in HEK293 Cells
Antimicrobial resistance (AMR) is widely acknowledged as one of the most serious public health threats facing the world, yet the private sector finds it challenging to generate much-needed medicines. As an alternative discovery approach, a small array of diarylimidazoles was screened against the ESK...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD040208 | Pride
Diarylimidazole Mib-ms Kinases Hek293 Antimicrobials 
UnknownTotal and Regional Brain Volumes in Fetuses With Congenital Heart Disease.
Not available
S-EPMC7616254 | biostudies-literature
TranscriptomicsRNA-seq of formalin-fixed, paraffin-embedded uninvolved terminal ileal tissue obtained from ileo-colic resection surgeries of Crohns disease and control patients
The interpretation of transcriptional profiling studies of intestinal tissue from Crohns disease patients and control patients can be confounded by differing proportions of cell subsets (e.g. immune cells) present in these samples. In this study, we aimed to control for cellular composition using st...
ORGANISM(S): Homo sapiens 
2018-05-22 | E-MTAB-5783 | biostudies-arrayexpress
ProteomicsSpecific Gut Microbial Enzymes Drive Colitis Promotion by Triclosan
Triclosan (TCS), an antimicrobial agent in thousands of consumer products, is a risk factor for colitis and colitis-associated colorectal cancer. While the intestinal toxicities of TCS require the presence of gut microbiota, the molecular mechanisms involved have not been defined. Here we show that ...
ORGANISM(S): human gut metagenome 
2021-11-04 | PXD025887 | Pride
Triclosan Gut microbiome Lc-ms/ms 
TranscriptomicsMicroarray of formalin-fixed, paraffin-embedded uninvolved terminal ileal tissue obtained from ileo-colic resection surgeries of Crohn’s disease and control patients
The interpretation of transcriptional profiling studies of intestinal tissue from Crohn’s disease patients and control patients can be confounded by differing proportions of cell subsets (e.g. immune cells) present in these samples. In this study, we aimed to control for cellular composition using s...
ORGANISM(S): Homo sapiens 
2018-05-22 | E-MTAB-5790 | biostudies-arrayexpress
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