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TranscriptomicsA compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupy CBF-MYH11/RUNX1 target genes
Different mechanisms for CBF-MYH11 function in acute myeloid Leukemia (AML) with inv(16) have been proposed such as tethering of RUNX1 outside the nucleus, interference with transcription factor complex assembly and recruitment of histone deacetylases, all resulting in transcriptional repression of ...
ORGANISM(S): Homo sapiens 
2013-09-09 | E-GEOD-46044 | biostudies-arrayexpress
TranscriptomicsNucleosome positioning in A549 cells before/after NME2 induction
Previous studies have analyzed patterns of transcription, transcription factor (TF) binding or mapped nucleosome occupancy across the genome. These suggest that the three aspects are genetically connected but the cause and effect relationships are still unknown. For example, physiologic TF binding ...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-40363 | biostudies-arrayexpress
GenomicsRegulation of bifurcating B cell trajectories by mutual antagonism between IRF4 and IRF8 (ChIP-Seq)
Upon antigen recognition B cells undertake a bifurcated response in which some cells rapidly differentiate into plasmablasts while others undergo affinity maturation in germinal centers (GC). We uncover a double negative feedback loop between interferon regulatory factors IRF4 and IRF8, which regula...
ORGANISM(S): Mus musculus 
2015-08-25 | E-GEOD-70710 | biostudies-arrayexpress
GenomicsTranscriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4 (ChIP-seq)
Temporal analysis of Irf4 and PU.1 genome binding during B cell activation and differentiation in vitro using antigen (NP-Ficoll) CD40L and IL-2/4/5 cytokines (see Molecular Systems Biology 7:495 for details of cellular system). The results provide insight in the target genes and binding specificity...
ORGANISM(S): Mus musculus 
2013-05-04 | E-GEOD-46607 | biostudies-arrayexpress
UnknownEvaluating educational interventions to increase breast density awareness among Latinas: A randomized trial in a Federally Qualified Health Center.
Not available
S-EPMC8837698 | biostudies-literature
TranscriptomicsSimple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
Genome-scale studies have revealed extensive co-localization of transcription factors in a given cell type as well as substantial differences in the binding patterns of specific transcription factors between cell types. Several mechanisms have been proposed to explain these observations, including t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21512 | biostudies-arrayexpress
UnknownMachine Learning on 50,000 Manuscripts Shows Increased Clinical Research by Academic Cardiac Surgeons.
Not available
S-EPMC11602380 | biostudies-literature
ProteomicsProteomic and phosphoproteomic profiling of ARPE19 cells and Abca4-/-Rdh8-/- mice exposed to stress
To obtain an unbiased, thorough understanding of the biological pathways implicated in atRAL-induced cytotoxicity and PDE inhibitor-mediated cytoprotection, we performed a mass spectrometry-based quantitative proteomic analysis of ARPE19 cells, using stable-isotope labeling of amino acids in cell cu...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-01-26 | PXD035841 | Pride
Phosphodiesterases Vision Cell culture Stress Neuroprotection Neurodegeneration Retina Lc-ms/ms 
Transcriptomicstranscriptome analysis of differentially expressed genes in the harlequin (hlq) mutant
Plant growth and development is continuous and modular, a combination that allows morphogenesis by controlled cell division and elongation and serves to facilitate plantsM-bM-^@M-^Y adaptations to changing environments. Plasticity is achieved through integration of external and internal signals to ...
ORGANISM(S): Arabidopsis thaliana 
2014-06-03 | E-GEOD-45806 | biostudies-arrayexpress
UnknownEffect of metformin on microvascular outcomes in patients with type 2 diabetes: A systematic review and meta-analysis.
Not available
S-EPMC9064963 | biostudies-literature
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