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ProteomicsTrans-synaptic dwelling of SARS-CoV-2 particles perturbs neural synapse organization and function
we performed mass spectrometry-based differential proteomics on single cortical organoids infected in the presence or absence of SARS-CoV-2 to identify the molecular perturbations caused by the virus.
ORGANISM(S): Homo sapiens (Human) 
2024-02-16 | PXD036485 | Pride
Ptms Nanolc-msms Single-organoid proteomics Quantification 
ProteomicsHarnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types
Mead BE, Ordovas-Montanes J, Braun AP, Levy LE, Bhargava P, Szucs MJ, Ammendolia DA, MacMullan MA, Zheng Y, Yin X, Hughes TK, Wadsworth MH, Ahmad R, Rakoff-Nahoum S, Carr SA, Langer R, Collins JJ, Shalek AK, Karp JM. BMC Biology 2018. Background: Single-cell genomic methods now provide unprecedent...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2017-07-20 | MSV000081369 | MassIVE
UnknownFrom fuzziness to precision medicine: on the rapidly evolving proteomics with implications in mitochondrial connectivity to rare human disease.
Not available
S-EPMC7820543 | biostudies-literature
ProteomicsHypoxic injury triggers maladaptive repair in human kidney organoids
Reduction in blood supply to the kidneys occurs to certain extent during kidney injury (AKI). Individuals who suffered AKI are at risk of developing chronic kidney disease (CKD) through a maladaptive repair process. At present, no therapies exist to prevent the AKI to CKD transition. Here, we presen...
ORGANISM(S): Homo sapiens (Human) 
2026-06-26 | PXD042882 | Pride
Acute kidney injury Metabolomics Organoids Chronic kidney disease Transcriptomics Maladaptive regeneration Proteomics Hypoxia 
UnknownSingle-cell RNA sequencing and proteomics uncover SIRPα-CD47 immune checkpoint and glycolysis-driven immune evasion in cardiac myxoma.
Not available
S-EPMC12433983 | biostudies-literature
ProteomicsA Study on the Inflammatory Response of the Brain in Neurosyphilis
Neurosyphilis (NS) is a clinical condition caused by infection of the central nervous system (CNS) by Treponema pallidum (Tp) that can lead to asymptomatic meningitis and more serious neurological diseases, such as dementia and blindness. However, current studies on the pathogenesis of NS are limite...
ORGANISM(S): Homo Sapiens 
PXD053294 |
ProteomicsPrecision-engineered organoids of the human fallopian tube
The fallopian tubes are essential to several physiological and pathological processes from pregnancy to ovarian cancer. However, current in vitro models to study their pathophysiology were validated using two-dimensional (2D) tissue sections and measuring the organoid response to female hormone stim...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-12 | MSV000092646 | MassIVE
ProteomicsProteomics on pancreatic ductal organoids
Primary human pancreatic ductal organoids (HPDO) have emerged as a model to study pancreas biology and model disease like pancreatitis and pancreatic cancer. Yet, donor material availability, genetic variability and a lack of extensive benchmarking to healthy and disease pancreas limits the range of...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2025-11-10 | PXD068063 | Pride
Pancreatic ductal organoids  porcine pancreas  chemical screen  cross-species comparison  scrna-seq profile  proteome profile 
ProteomicsMHC1-TIP: scalable multimodal immunopeptidome profiling of low-input samples
We developed MHC1-TIP: an optimized mild acid elution-based immunopeptidomics workflow that leverages data independent acquisition and the Astral mass analyzer to enable scalable, single-tube and cost-effective MHC-I ligandome profiling. This dataset includes immunopeptidomics and proteomics data fr...
ORGANISM(S): Homo sapiens (Human) 
2025-12-18 | PXD065279 | Pride
Tumours Organoids Proteomics Heterogeneity Melanoma Immunopeptidomics 
UnknownLiquid Biopsy-Multiomics Link Adhesion Pathway Dysregulation to Kidney Injury Severity.
Not available
S-EPMC12545944 | biostudies-literature
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