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ProteomicstRNA modification reprogramming of Plasmodium falciparum as a feature of artemisinin resistance
Artemisinin (ART)-resistant Plasmodium falciparum (Pf) threatens global malaria control. Resistance, driven by mutations in Pfk13, is multifaceted but quiescence plays a central role. Epigenetic regulation may contribute, given that only a percentage of parasites survive a pulse of the active drug m...
ORGANISM(S): Plasmodium falciparum 
2024-06-22 | PXD043747 | Pride
Plasmodium Artemisinin Rna modification 
ProteomicsCohesin is involved in transcriptional repression of invasion-related genes
The most virulent human malaria parasite, Plasmodium falciparum, has a complex life cycle between its human host and mosquito vector. Each stage is driven by a specific transcriptional program, but with a relatively high ratio of genes to specific transcription factors, it is unclear how genes are a...
ORGANISM(S): Homo sapiens (Human) 
2023-10-04 | PXD035225 | Pride
Plasmodium Smc3 Cohesin 
ProteomicsCytosine methylation of tRNA in Plasmodium falciparum disrupts translational homeostasis to prime for sexual commitment
Malaria parasites have evolved a well-adjusted developmental program to progress through the complex life cycle in the human and mosquito host. Here we identify cytosine methylation of tRNAAsp (GTC) as being critical to maintain stable protein synthesis under cellular stress. Using conditional knock...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-02-13 | PXD024769 | Pride
Epitranscriptomics Dmt2 Trna Plasmodium 
ProteomicsHydrogen sulfide sensitizes Acinetobacter baumannii to killing by antibiotics.
The production of endogenous hydrogen sulfide (H2S) has been shown to confer antibiotic tolerance in all bacteria studied to date. Therefore, this mediator has been speculated to be a universal defense mechanism against antibiotics in bacteria. This is assuming that all bacteria produce endogenous H...
ORGANISM(S): Acinetobacter baumannii AB_TG2631 
2021-06-08 | PXD020384 | Pride
Acinetobacter baumannii Hydrogen sulfide Amr 
ProteomicsEpitranscriptomic regulation of the oxidative stress response by the radical S-adenosylmethionine methyltransferase RlmN
Bacteria possess elaborate systems to manage reactive oxygen and nitrogen species (ROS) arising from exposure to the mammalian immune system and environmental stresses. Here we report the discovery of an ROS-sensing RNA-modifying enzyme that regulates translation of stress-response proteins in the g...
ORGANISM(S): Enterococcus faecalis (Streptococcus faecalis) 
2023-05-09 | PXD038178 | Pride
E. faecalis Rlmn Oxidative stress Epitranscriptome 
UnknownExploring the virulence gene interactome with CRISPR/dCas9 in the human malaria parasite
Not available
S-SCDT-MSB-20-9569 | biostudies-other
UnknownCohesin contributes to transcriptional repression of stage-specific genes in the human malaria parasite
Not available
S-SCDT-10_15252-EMBR_202357090 | biostudies-other
UnknowntRNA epitranscriptomics and biased codon are linked to proteome expression
Not available
S-SCDT-MSB-17-8009 | biostudies-other
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