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ProteomicsA slit-diaphragm-associated protein network for dynamic control of renal filtration
The filtration of blood in the kidney which is crucial for mammalian life is determined by the slit-diaphragm (SD), a proteinaceous junction between the foot processes of renal podocytes. Based on studies of structure and function the SD has been hypothesized to operate as a final barrier or as a ‘m...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-09-20 | PXD034356 | Pride
Ap-ms Kidney Podocytes Rat Neph1 Nephrin Podocin Mouse Slit-diaphragm Orbitrap Renal filtration Lc-ms/ms 
TranscriptomicsChanges in mouse kidney glomerular gene expression following dendrin knockout
Glomerular podocyte cells are critical for the function of the renal ultrafiltration barrier. The highly specialized cell-cell junction of podocytes, the slit diaphragm, has a central role in the filtration barrier. Dendrin is a poorly characterized cytosolic component of the slit diaphragm in where...
ORGANISM(S): Mus musculus 
2014-05-20 | E-GEOD-47606 | biostudies-arrayexpress
UnknownOxidative Stress Contributes to Slit Diaphragm Defects Caused by Disruption of Endocytosis.
Not available
S-EPMC10851022 | biostudies-literature
UnknownTyrosine Phosphorylation of CD2AP Affects Stability of the Slit Diaphragm Complex.
Not available
S-EPMC6622410 | biostudies-literature
UnknownNephrin is specifically located at the slit diaphragm of glomerular podocytes.
Not available
S-EPMC22170 | biostudies-literature
Unknownbeta-Arrestin2 mediates nephrin endocytosis and impairs slit diaphragm integrity.
Not available
S-EPMC1564064 | biostudies-literature
UnknownRap1 Activity Is Essential for Focal Adhesion and Slit Diaphragm Integrity.
Not available
S-EPMC8972170 | biostudies-literature
UnknownSelective endocytosis controls slit diaphragm maintenance and dynamics in Drosophila nephrocytes.
Not available
S-EPMC9355562 | biostudies-literature
OtherComparative phosphoproteomic analysis of mammalian glomeruli reveals conserved podocin C-terminal phosphorylation as a determinant of slit diaphragm complex architecture.
Data from ProteomeXchange, PXD ID: PXD001005. Experiment: 130104MaRiS_TpD, file: 0089-130104MaRiS04TpD.mzml. Published as part of Proteomics. 2014 Nov 25 . From the Abstract: {{i}} Glomerular biology is dependent on tightly controlled signal transduction networks that control phosphorylation of sig...
ORGANISM(S): Rat 
GPM32320007078 | GPMDB
Resource Reanalysis 
UnknownA slit-diaphragm-associated protein network for dynamic control of renal filtration.
Not available
S-EPMC9616960 | biostudies-literature
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