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TranscriptomicsExpression data from MDA-MB-231 parental and xenograft tumor cells treated with Smac mimetic SM-164.
Small-molecule Smac mimetics target inhibitor of apoptosis (IAP) proteins to induce TNFα-dependent apoptosis in cancer cells and several Smac mimetics have been advanced into clinical development as a new class of anticancer drugs. However, preclinical studies have shown that only a small subset of...
ORGANISM(S): Homo sapiens 
2012-03-01 | E-GEOD-33827 | biostudies-arrayexpress
GenomicsThe influence of the Smac mimetic BV6 on the rhabdomyosarcoma cell line RH30
The influence of the Smac mimetic BV6 on the rhabdomyosarcoma cell line RH30
PRJNA928379 | ENA
TranscriptomicsMicroarray analysis of in-vitro differentiated murine Th17 cells in the presence of the smac mimetic AT406, or DMSO as control, and undifferentiated naive CD4 T cells.
Transcriptome analysis to investigate the effects of the smac mimetic AT406 on the differentiation of murine Th17 cells compared to DMSO controls, and to investigate the transriptome of murine Th17 cells compared to control undifferentiated naive CD4 T cells.
ORGANISM(S): Mus musculus 
2019-08-15 | E-MTAB-7894 | biostudies-arrayexpress
ProteomicsInteraction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP dependent manner
Metastatic malignant melanoma is the deadliest skin cancer type, and it is characterized by its high resistance to apoptosis. The main driving mutations in melanoma cause hyperactivation of genes within the ERK pathway, with BRAF mutations being the most frequent ones, followed by NRAS, NF1 and MEK ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-18 | PXD032781 | Pride
Mst2 Apoptosis Lats1 Smac Hippo Iap Melanoma 
TranscriptomicsExpression data from MDA-MB-231 parental and xenograft tumor cells treated with Smac mimetic SM-164.
Small-molecule Smac mimetics target inhibitor of apoptosis (IAP) proteins to induce TNFα-dependent apoptosis in cancer cells and several Smac mimetics have been advanced into clinical development as a new class of anticancer drugs. However, preclinical studies have shown that only a small subset of ...
ORGANISM(S): Homo sapiens 
2012-03-01 | GSE33827 | GEO
UnknownTargeting triple-negative breast cancers with the Smac-mimetic birinapant.
Not available
S-EPMC7492458 | biostudies-literature
TranscriptomicsThe influence of the Smac mimetic BV6 on the rhabdomyosarcoma cell line RH30
The effect of the Smac mimetic BV6 on the transcriptional regulation in the alveolar rhabdomyosarcoma cell line RH30 was investigated by bulk RNA-sequencing. To this end, RH30 cells were treated with 5 µM BV6 for 24 h, or left untreated. Here, a regulation of several NF-κB target genes could be obse...
ORGANISM(S): Homo sapiens 
2023-04-04 | GSE223787 | GEO
TranscriptomicsTargeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma (Agilent Arrays)
Chronic active B cell receptor (BCR) signaling, a hallmark of the ABC subtype of diffuse large B cell lymphoma (DLBCL), engages the CARD11-MALT1-BCL10 (CBM) adapter complex to activates IkappaB kinase (IKK) and the classical NF-kappaB pathway. Here we show that the CBM complex includes the E3 ubiqui...
ORGANISM(S): Homo sapiens 
2016-09-01 | E-GEOD-73281 | biostudies-arrayexpress
UnknownThe SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells.
Not available
S-EPMC6941266 | biostudies-literature
UnknownSmac mimetic suppresses tunicamycin-induced apoptosis via resolution of ER stress.
Not available
S-EPMC6377606 | biostudies-literature
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