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UnknownNonquantal transmission at the vestibular hair cell-calyx synapse: KLV currents modulate fast electrical and slow K+ potentials.
Not available
S-EPMC9926171 | biostudies-literature
UnknownPTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis.
Not available
S-EPMC6128396 | biostudies-literature
ProteomicsIsolation and characterization of multi-protein complexes enriched in the K-Cl co-transporter 2 from brain plasma membranes
Kcc2 plays a critical role in determining the efficacy of synaptic inhibition, however, the cellular mechanism neurons use to regulate its membrane trafficking, stability and activity are ill-defined. To address these issues, we used affinity purification to isolate stable multi-protein complexes of...
ORGANISM(S): Mus musculus (Mouse) 
2020-10-22 | PXD021368 | Pride
Kcc2 Phosphorylation Proteome Interactome 
ProteomicsStudying the role of LMTK3 in the brain
Studying the phosphorylation events related to LMTK3 and its associated proteins in the brain. LMTK3 appears to be associated with the excitatory and inhibitory synaptic machinery, therefore this study was carried out to examine it's role in modulating inhibitory synapses.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-05-22 | PXD050212 | Pride
Synapse Phosphorylation Gaba Mouse Lmtk3 Brain 
UnknownIsolation and Characterization of Multi-Protein Complexes Enriched in the K-Cl Co-transporter 2 From Brain Plasma Membranes.
Not available
S-EPMC7643010 | biostudies-literature
ProteomicsThe PDE4 inhibitor apremilast modulates ethanol responses in Gabrb1 S409A knock-in mice via PKA-dependent and independent mechanisms
We previously showed that the PDE4 inhibitor apremilast reduces ethanol consumption in mice by protein kinase A (PKA) and GABAergic mechanisms. Preventing PKA phosphorylation of GABAA 3 subunits partially blocked apremilast-mediated decreases in alcohol drinking. Here, we produced Gabrb1-S409A knock...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-06 | PXD052839 | Pride
Gaba a receptor Mutany Apremilast Pka Gabrb1 Ethanol 
ProteomicsHDAC8-mediated inhibition of EP300 drives a transcriptional state that increases melanoma brain metastasis
Melanomas are heterogeneous and adopt multiple transcriptional states that can confer an invasive phenotype and resistance to therapy. Little is known about the epigenetic drivers of these cell states, limiting our ability to regulate melanoma heterogeneity and tumor progression. Here we identify st...
ORGANISM(S): Homo sapiens (Human) Brassica oleracea var. botrytis (Cauliflower) 
2023-09-26 | PXD044471 | Pride
Brain metastasis Melanoma Hdac8 Acetylation 
ProteomicsSpectrin-beta 2 facilitates the selective accumulation of GABAA receptors at somatodendritic synapses
Fast synaptic inhibition is dependent on targeting specific GABAAR subtypes to dendritic and axon initial segment (AIS) synapses. Synaptic GABAARs are typically assembled from 1-3, and subunits. Here, we isolate distinct GABAARs from the brain and interrogate their composition using quantitative pr...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-10 | PXD038703 | Pride
Ais Gaba a receptors Spectrins 
UnknownThermal imaging through hot emissive windows.
Not available
S-EPMC11569156 | biostudies-literature
TranscriptomicsExpression data from Transgenic mice skin expressing deltaNp63alpha
We developed a Tet-inducible system to express deltaNp63alpha isoform under the control of keratin 5 promoter. Transgenic mice, which were Bigenic (BG) developed a severe skin phenotype with abnormal keratinocyte differentiation and defects in hair follicle development and cycling. Skin samples from...
ORGANISM(S): Mus musculus 
2010-04-28 | E-GEOD-20514 | biostudies-arrayexpress
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