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Glycosite mapping and structural dynamics of TIM family immune checkpoints enabled by mucinase SmE

Mucin-domain glycoproteins are densely O-glycosylated and play key roles in a host of biological functions. In particular, the T-cell immunoglobulin and mucin-domain containing family of proteins (TIM-1, 3, 4) decorate immune cells and act as key checkpoint inhibitors in cancer. However, their dense...

ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse)

2023-09-27 | PXD039583 | Pride