Sort   by:  
 Page size 
ProteomicsIncreased soluble HLA in COVID-19 present a disease-related, diverse immunopeptidome associated with T cell immunity
HLA-presented antigenic peptides are central components of T cell-based immunity in infectious disease. Beside HLA molecules on cell surfaces, soluble HLA molecules (sHLA) are released in the blood suggested to impact cellular immune responses. We demonstrated that sHLA levels were significantly inc...
ORGANISM(S): Homo sapiens (Human) 
2022-11-23 | PXD029567 | Pride
Covid-19 Immunopeptidome Soluble hla 
ProteomicsSAPrIm 2.0: A semi-automated protocol for mid-throughput soluble HLA immunopeptidomics
Human leukocyte antigen (HLA) molecules are pivotal in guiding human adaptive immune responses through their presentation of peptide ligands, collectively known as the immunopeptidome. This process is central to the development of cancer immunotherapies, such as vaccines and T-cell therapies. Profil...
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD058880 | Pride
Shla Hla Mass spectrometry Mhc Saprim Immunopeptidomics Soluble hla Plasma immunopeptidomics 
ProteomicsMapping the soluble human leukocyte antigen peptidome of pleural effusions reveals lung and tumor-associated antigens
Soluble HLA (sHLA) molecules released to the plasma, carry their original peptide cargo and provide insight into the protein synthesis and degradation schemes of their source cells and tissues. Other body fluids, such as pleural effusions, may also contain sHLA-peptide complexes, and can potentially...
ORGANISM(S): Homo sapiens (Human) 
2022-05-25 | PXD027766 | Pride
Tumor antigens Immunopeptisome Pleural effusion Cancer/testis antigens Hla peptidome Lung cancer Lc-ms/ms 
ProteomicsTumor-associated peptides can be detected from the plasma-derived soluble immunopeptidome in human hepatocellular carcinoma patients – A pre-clinical study on the correlation of the soluble and hepatocellular carcinoma-derived membranous immunopeptidomes.
Abstract Background and aims. Hepatocellular carcinoma (HCC) shows limited response to checkpoint inhibitors, leaving opportunity for antigen-based immunotherapy and improved disease monitoring. This study evaluates plasma-derived soluble HLA-I (sHLA-I) peptidome as a minimally invasive source of tu...
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD066255 | Pride
Hepatocellular carcinoma Immunopeptidomics Soluble hla Shla 
ProteomicsHLA class II ligandome from HOM-2 and JY cell lines (HLA-DR an HLA-DP ligands)
A high-throughput mass spectrometry analysis was used to identify more than 16,000 cell peptides bound to several HLA-DR and -DP class II molecules isolated from large amounts of two human cell lines (HOM-2 and JY).
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD028006 | Pride
Hla-dr Hla-dp 
ProteomicsIdentification of tumor antigens among the HLA peptidomes of Glioblastoma tumors and plasma
Glioblastoma multiforme (GBM) is the most aggressive brain tumor with poor prognosis to most patients. Immunotherapy of GBM is a potentially beneficial treatment option, whose optimal implementation may depend on familiarity with tumor specific antigens, presented as HLA peptides by the GBM cells. F...
ORGANISM(S): Homo sapiens (Human) 
2019-06-11 | PXD008127 | Pride
Hla peptidome Shla Mhla Glioblastoma Plasma Early detection 
ProteomicsMHC peptides presentation is limited by availability of empty HLA molecules rather than the supply of peptides ligands
Whether the presentation levels of the major histocompatibility complex (MHC, called the human leukocytes antigens, HLA, in humans) is limited by the availability of peptide ligands for loading or by the supply of empty MHC molecules, is a yet unresolved issue. This study aims to tackle this dilemma...
ORGANISM(S): Homo sapiens (Human) 
2018-05-10 | PXD007596 | Pride
Interferon Mhc Peptidome Immunopeptidome Hla 
ProteomicsHLA class II peptidome analysis using data-dependent and data-independent acquisition
HLA class II peptides were purified from Maver-1 and DOHH2 cells and measured on the Q Exactive platform by data-dependent and data-independent acquisition.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-22 | MSV000081729 | MassIVE
UnknownSoluble HLA-G levels in seminal plasma are associated with HLA-G 3'UTR genotypes and haplotypes.
Not available
S-EPMC6772099 | biostudies-literature
ProteomicsIdentification of tumor antigens among the HLA peptidomes of Glioblastoma tumors and plasma
Glioblastoma multiforme (GBM) is the most aggressive brain tumor with poor prognosis to most patients. Immunotherapy of GBM is a potentially beneficial treatment option, whose optimal implementation may depend on familiarity with tumor specific antigens, presented as HLA peptides by the GBM cells. F...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084343 | MassIVE
Sort   by:  
 Page size