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ProteomicsKRAS G12V spliced neoepitope is produced by proteasomes
This dataset contains further evidence that the HLA-A*02:01+ KRAS G12V+ spliced neoepitope we previously identified (Mishto et al., Front. Immunol. 2019) is produced by proteasomes in various experimental conditions
ORGANISM(S): Homo sapiens (Human) 
2022-09-05 | PXD024528 | Pride
Mass spectrometry Epitope discovery Peptide splicing Proteasome Cis-spliced peptides Kras 
ProteomicsContribution of proteasome-catalyzed peptide cis-splicing to viral targeting by CD8+ T cells in HIV-1 infection
Peptides generated by proteasome-catalyzed splicing of non-contiguous amino acid sequences have been shown to constitute a source of non-templated human leukocyte antigen class I (HLA-I) epitopes, but their role in pathogen-specific immunity remains unknown. CD8+ T cells are key mediators of human i...
ORGANISM(S): Homo sapiens (Human) HIV-1 vector pNL4-3 
2019-11-25 | PXD015489 | Pride
Spliced epitope Peptide splicing Viral escape Mass spectrometry Cd8+ t cell Epitope discovery Proteasome Human leukocyte antigen Immunopeptidome Human immunodeficiency virus 
UnknownPotential Mimicry of Viral and Pancreatic β Cell Antigens Through Non-Spliced and <i>cis</i>-Spliced <i>Zwitter</i> Epitope Candidates in Type 1 Diabetes.
Not available
S-EPMC8082463 | biostudies-literature
UnknownProteasomes generate spliced epitopes by two different mechanisms and as efficiently as non-spliced epitopes.
Not available
S-EPMC4822137 | biostudies-literature
UnknownAn in silico-in vitro Pipeline Identifying an HLA-A*02:01+ KRAS G12V+ Spliced Epitope Candidate for a Broad Tumor-Immune Response in Cancer Patients.
Not available
S-EPMC6872521 | biostudies-literature
UnknownSite-specific HNK-1 epitope on alternatively spliced fibronectin type-III repeats in tenascin-C promotes neurite outgrowth of hippocampal neurons through contactin-1.
Not available
S-EPMC6328190 | biostudies-literature
UnknownMapping the MHC Class I-Spliced Immunopeptidome of Cancer Cells.
Not available
S-EPMC12032831 | biostudies-literature
UnknownDesign of multi-epitope vaccine candidate against Brucella type IV secretion system (T4SS).
Not available
S-EPMC10414599 | biostudies-literature
UnknownProteasome-Generated <i>cis</i>-Spliced Peptides and Their Potential Role in CD8<sup>+</sup> T Cell Tolerance.
Not available
S-EPMC7943738 | biostudies-literature
ProteomicsKRAS G12V digestion by 20S proteasome
KRAS is a well known tumor associated antigen. It’s a GTPase that functions as molecular switch in regulatory pathways responsible for proliferation and survival. It’s frequently mutated in a variety of cancers. One of the possible driver mutations is G12V substitution, which impairs KRAS GTPase act...
ORGANISM(S): Homo sapiens (Human) 
2019-10-24 | PXD015580 | Pride
Proteasome Cancer Kras Digestion Lc-ms/ms 
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