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Biogenesis of motile cilia in multiciliated cells (MCCs) is coupled to large-scale biosynthesis of force generating dynein motors. Shulin inhibits pre-assembled ODA (outer dynein arm) motors by packaging them into a closed conformation preventing aberrant off-target interactions with cellular microt...
ORGANISM(S): Homo sapiens (Human) 
2025-07-31 | PXD052722 | Pride
Proteomics experiments commonly aim to estimate and detect differential abundance across all expressed proteins. Within this experimental design, some of the most challenging measurements are small fold changes for lower abundance proteins. While bottom-up proteomics methods are approaching comprehe...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2018-04-05 | PXD007683 | Pride
Poison frogs sequester chemical defenses from their diet of leaf litter arthropods for defense against predation. Little is known about the physiological adaptations that confer this unusual bioaccumulation ability. We conducted an alkaloid-feeding experiment with the Diablito poison frog (Oophaga s...
ORGANISM(S): Oophaga sylvatica 
2021-01-25 | PXD021216 | Pride
Dengue is a mosquito-borne virus infection affecting half of the world’s population for which therapies are lacking. The role of T and NK-cells in protection/immunopathogenesis remains unclear for dengue for dengue. We performed a longitudinal phenotypic, functional and transcriptional analyses of T...
ORGANISM(S): Homo sapiens (Human) 
2025-05-21 | PXD061694 | Pride
Triplicate samples of donor matched ex vivo generated macrophage subtypes M1, M2a, M2c compared against the M0 control analysed using TMT-based 11plex quantitative proteomics.
ORGANISM(S): Homo sapiens (Human) 
2023-09-04 | PXD032801 | Pride
Triplicate samples of donor matched ex vivo generated macrophage subtype M1 cells treated with and without dexamethasone compared against the M0 control analysed using TMT-based 11plex quantitative proteomics.
ORGANISM(S): Homo sapiens (Human) 
2023-09-04 | PXD032967 | Pride
Triplicate samples of donor matched ex vivo generated macrophage subtype M1 cells treated with and without dexamethasone compared against the M0 control analysed using TMT-based 11plex quantitative proteomics.
ORGANISM(S): Homo sapiens (Human) 
2023-09-04 | PXD032966 | Pride
Triplicate samples of donor matched ex vivo generated macrophage subtypes M1, M2a, M2c compared against the M0 control analysed using TMT-based 11plex quantitative proteomics.
ORGANISM(S): Homo sapiens (Human) 
2023-09-04 | PXD032823 | Pride
Triplicate samples of donor matched ex vivo generated macrophage subtype M1 cells treated with and without dexamethasone compared against the M0 control analysed using TMT-based 11plex quantitative proteomics.
ORGANISM(S): Homo sapiens (Human) 
2023-09-04 | PXD032905 | Pride
The cell bodies of hypothalamic magnocellular neurones are densely packed in the hypothalamic supraoptic nucleus whereas their axons project to the anatomically discrete posterior pituitary gland. We have taken advantage of this unique anatomical structure to establish proteome and phosphoproteome d...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-04-12 | PXD040870 | Pride
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