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ProteomicsProteomic analysis of the liver isolated from the double (apolipoprotein E and endothelial nitric oxide synthase) knockout mice reveals decreased expression of major urinary proteins (MUPs)
Nitric oxide (NO) is a crucial gaseous signaling molecule engaged in a variety of physiological and pathological processes. It is produced by three isoenzymes called nitric oxide synthases (NOS): neuronal, inducible and endothelial NOS (eNOS). eNOS-derived NO plays an important role in endothelium-d...
ORGANISM(S): Mus musculus (Mouse) 
2018-03-05 | PXD006642 | Pride
Proteomics Liver Mup Apolipoprotein e Enos 
ProteomicsThe effect of opioid system inhibition on the Hmmr and Col1a1/ Col3a1 gene expression in relation to atherosclerotic plaque formation in aorta.
Atherosclerosis is the most common cardiovascular disease, leading to complications such as myocardial infarction and stroke, the main but not the only causes of which are lipid accumulation and inflammation. In this study, we investigated whether opioid receptor blockade impacts factors involved in...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-27 | PXD064451 | Pride
Aorta Opioid system Naloxone 
ProteomicsDiminazene aceturate (DIZE) stabilizes atherosclerotic plaques and attenuates hepatic steatosis in apolipoprotein E knockout mice by influencing macrophages polarization and taurine biosynthesis
Atherosclerosis and nonalcoholic fatty liver disease (NAFLD) are leading causes of morbidity and mortality in the Western countries. NAFLD is an important independent risk factor for the development of atherosclerosis. The renin-angiotensin system (RAS) with its two main opposing effectors: angioten...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD022829 | Pride
Atherosclerosis Dize Macrophages polarization Fatty liver Apoe-knockout mice Ace2 
ProteomicsProteomic analysis of mitochondria isolated from the frontal cortex and hippocampus of apolipoprotein E knockout mice treated with Alda-1, an activator of mitochondrial aldehyde dehydrogenase (ALDH2)
Recently, it has been shown that mitochondrial dysfunction and oxidative stress play important roles in the pathogenesis of neurodegeneration. Mitochondrial aldehyde dehydrogenase (ALDH2), an enzyme responsible for the detoxification of reactive aldehydes – the end products of lipid peroxidation, i...
ORGANISM(S): Mus musculus (Mouse) 
2017-02-23 | PXD004022 | Pride
Alzheimer’s disease Brain Aldh2 Mitochondria Apolipoprotein e 
ProteomicsProteomics of human cardiac conduction system
The scientific aim of the study is to identify proteomic characteristic of the human SAN (sinoatrial node and AVN (atrioventricular node)in the comparison to right atrium and ventricle in the population of young healthy adults using modern proteomic analysis techniques.
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD051011 | Pride
Heart Proteomics Human 
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