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TranscriptomicsGene expression profiles of human breast cancer cell lines MCF-7, T47D and MDA-MB-231 co-cultured with 3T3-L1 adipocytes.
Obesity is a known risk factor for breast cancer. To identify genes and underlying pathways in human breast cancer cells affected by interaction with mature adipocytes, two estrogen-receptor positive (ER+) breast cancer cell lines, MCF-7 and T47D, and the triple-negative (TN) breast cancer cell line...
ORGANISM(S): Homo sapiens 
2018-06-22 | E-MTAB-6855 | biostudies-arrayexpress
TranscriptomicsDevelopment and Diversification of Retinal Amacrine Interneurons at Single Cell Resolution
The vertebrate retina uses diverse neuronal cell types arrayed into complex neural circuits to extract, process and relay information from the visual scene to the higher order processing centers of the brain. Amacrine cells, a diverse class of inhibitory interneurons, are thought to mediate the maj...
ORGANISM(S): Mus musculus 
2009-05-31 | E-GEOD-12601 | biostudies-arrayexpress
ProteomicsInvestigation upon the state of p53 as well as interaction partners, in so much as can be learned from using the multi-component v5-dTag system.
Chromatin modifications provide additional context-dependence for DNA sequence-based gene regulation. Binding sites of the transcription factor (TF) and important tumour suppressor p53 are unusually diverse with regards to their chromatin accessibility and histone modifications, suggesting different...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-05 | PXD033674 | Pride
Trim24 Gene regulation Chromatin P53 
ProteomicsReadout of histone methylation by Trim24 locally restricts chromatin opening by p53
The genomic binding sites of the transcription factor (TF) and tumour suppressor p53 are unusually diverse in regards to their chromatin features, including histone modifications, opening the possibility that chromatin provides context-dependence for p53 regulation. Here, we show that the ability of...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-05 | PXD039553 | Pride
Trim24 p53 mouse 
GenomicsPolycomb preferentially targets stalled promoters of coding and non-coding transcripts
The Polycomb group (PcG) and Trithorax group (TrxG) of proteins are required for stable and heritable maintenance of repressed and active gene expression states. Their antagonistic function on gene control, repression for PcG and activity for TrxG, is mediated by binding to chromatin and subsequent ...
ORGANISM(S): Drosophila melanogaster 
2010-12-21 | E-GEOD-24521 | biostudies-arrayexpress
TranscriptomicsChromatin based modeling of transcription rates identifies the contribution of different regulatory layers to steady-state mRNA levels.
Messenger RNA levels in eukaryotes are balanced by two consecutive regulatory layers. Primary, transcriptional regulation at the level of chromatin and secondary, post-transcriptional regulation of the initial transcript in the cytoplasm. Each layer is individually studied in mechanistic detail, whi...
ORGANISM(S): Mus musculus 
2012-09-13 | E-GEOD-34473 | biostudies-arrayexpress
GenomicsRepressive and active histone methylation mark distinct promoters in human and mouse spermatozoa (Illumina)
In higher eukaryotes, histone methylation is involved in the maintenance of cellular identity during somatic development. During spermatogenesis, Since most nucleosomes are replaced by protamines during spermatogenesis . Iit is therefore unclear whether if histone modifications function in paternal ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-19889 | biostudies-arrayexpress
TranscriptomicsChromatin based modeling of transcription rates identifies the contribution of different regulatory layers to steady-state mRNA levels
Messenger RNA levels in eukaryotes are balanced by two consecutive regulatory layers. Primary, transcriptional regulation at the level of chromatin and secondary, post-transcriptional regulation of the initial transcript in the cytoplasm. Each layer is individually studied in mechanistic detail, whi...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-33252 | biostudies-arrayexpress
TranscriptomicsA chromatin-modifying function of JNK during stem cell differentiation
Signaling mediates cellular responses to extracellular stimuli. The c-Jun NH2-terminal kinase (JNK) pathway exemplifies one sub-group of Mitogen-activated protein (MAP) kinases, which besides established functions in stress response, also contributes to developmental processes by an unknown mechanis...
ORGANISM(S): Mus musculus 
2011-12-18 | E-GEOD-25532 | biostudies-arrayexpress
TranscriptomicsComplex patterns of accessibility discriminate sites of PcG repression, H4K16 acetylation and replication initiation
Full title: Complex patterns of genome accessibility discriminate sites of PcG repression, H4K16 acetylation and replication initiation Histone modifications have been proposed to regulate gene expression in part by modulating DNA accessibility and higher-order chromatin structure. However, there i...
ORGANISM(S): Drosophila melanogaster 
2010-03-16 | E-GEOD-17697 | biostudies-arrayexpress
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