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ProteomicsCysteamine inhibits glycine utilisation and disrupts virulence in Pseudomonas aeruginosa
Pseudomonas aeruginosa is a major opportunistic human pathogen which employs a myriad of virulence factors. In people with cystic fibrosis (CF) P. aeruginosa frequently colonises the lungs and becomes a chronic infection that evolves to become less virulent over time, but often adapts to favour pers...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2021-08-19 | PXD027156 | Pride
Pseudomonas aeruginosa Human 
ProteomicsRobust and High-Throughput Analytical Flow Proteomics Analysis of Cynomolgus Monkey and Human Matrices with Zeno SWATH Data Independent Acquisition
Modern mass spectrometers routinely allow deep proteome coverage in a single experiment. These methods are typically operated at nano and micro flow regimes, but they often lack throughput and chromatographic robustness, which is critical for large-scale studies. In this context, we have developed, ...
ORGANISM(S): Homo sapiens (Human) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2023-05-09 | PXD039414 | Pride
Dia Biofluids 7600 zenotof Tissues Zeno swath 
TranscriptomicsSerial Analysis of Gene Expression molecular signature for disease progression in Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fibrosing interstitial lung disease that is unresponsive to current therapy. While it carries a median survival of less than 3 years its rate of progression varies widely between patients. We hypothesized that studying the gene express...
ORGANISM(S): Homo sapiens 
2009-04-07 | E-GEOD-11665 | biostudies-arrayexpress
ProteomicsDifferentially expressed proteins wereassociated withtwo color morphs of Asian citrus psyllid, Diaphorina citri
Diaphorina citriis a vector of ‘CandidatusLiberibacter asiaticus,’(CLas), associated with citrus greening or Huanglongbing (HLB) disease in citrus. D. citriexhibits two group three different color morph variants, blueand non-blue (includes gray and yellow). Blue morphs have a greater capacity fo...
ORGANISM(S): Diaphorina citri (Asian citrus psyllid) 
2021-04-26 | PXD017150 | Pride
Color polymorphism Immunity Proteomics survey 
ProteomicsComparison of proteins in secretory/excretory products of the salmon louse, Lepeophtheirus salmonis.
Comparative Proteomics of the Secretory/Excretory products (SEPs) of 2 life stages L.salmonisusing LC-ESI-MS/MS.
ORGANISM(S): Lepeophtheirus salmonis 
2018-10-19 | PXD009391 | Pride
Esi-lc-ms/ms E/s Excretory/secretory products Ion-trap L. salmonis 
TranscriptomicsTranscription profiling by array of rat heart tissue treated with saline or doxorubicin to identify molecular mechanisms of doxorubicin cardiac toxicity
Doxorubicin induces cardiomypathy in oncology patients. This study is aimed at identifying molecular mechanisms of doxorubicin cardiac toxicity in rats. Transcription profiling of heart tissue of rats treated with saline or doxorubicin 1, 2 or 3 mg/kg/week by iv once per week for 2, 4 or 6 weeks. So...
ORGANISM(S): Rattus norvegicus 
2012-07-01 | E-MTAB-1168 | biostudies-arrayexpress
TranscriptomicsAge Map, Cerebellum (A)
To assess the transcriptional changes in different brain regions and spinal cord associated with aging and either a caloric restricted (CR) or ad libitum (AL) diet. cDNA microarray and quantitative PCR analyses were used to examine the transcriptomes of various neuronal tissues in young, middle aged...
ORGANISM(S): Mus musculus 
2009-06-21 | E-GEOD-8409 | biostudies-arrayexpress
TranscriptomicsTranscriptome of the maturing erythroblast
Understanding the pattern of gene expression and identifying the specific genes expressed during erythropoiesis is crucial for a synthesis of erythroid developmental biology. Here we have isolated four distinct populations of erythroblasts at successive erythropoietin-dependent stages of erythropoie...
ORGANISM(S): Homo sapiens 
2011-03-02 | E-GEOD-22552 | biostudies-arrayexpress
TranscriptomicsInhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [Illumina HumanHT-12 gene expression array]
All-trans-retinoic acid (ATRA) has been successfully used in therapy of acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukemia (AML) but the response of non-APL AML cases to ATRA-based treatment has been poor. Here we show that, via epigenetic reprogramming,...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-34672 | biostudies-arrayexpress
GenomicsInhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia [ChIP-Seq]
All-trans-retinoic acid (ATRA) has been successfully used in therapy of acute promyelocytic leukemia (APL), a cytogenetically distinct subtype of acute myeloid leukemia (AML) but the response of non-APL AML cases to ATRA-based treatment has been poor. Here we show that, via epigenetic reprogramming,...
ORGANISM(S): Homo sapiens 
2012-03-14 | E-GEOD-34725 | biostudies-arrayexpress
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