Sort   by:  
 Page size 
ProteomicsData in support of Anti-Aβ antibody treatment with Aducanumab modified the proteome of senile plaques and surrounding tissue and altered disease progression in a transgenic mouse model of Alzheimer’s disease.
Alzheimer’s disease (AD) is the most comment type of dementia and is characterized by neuronal loss and cognitive decline. Aggregation and accumulation of Aβ proteoforms into senile plaques (SP) is one of the key hallmarks of the disease. The accumulation of Aβ in particular in hippocampus has been ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-25 | PXD021918 | Pride
Pasef Ad Proteomics A-beta 
ProteomicsBranch retinal vein occlusion in a porcine model
Branch retinal vein occlusion (BRVO) is a common retinal vascular disease, but global protein changes following the disease remain largely unelucidated. To bring new insights into pathological processes and elucidate potential therapeutic targets, large-scale retinal protein changes following BRVO w...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2015-07-30 | PXD001800 | Pride
Retina Brvo Pig 
ProteomicsProteome analysis of adipose-derived stem cells cultured under clinically relevant conditions in a wound healing perspective
There is a large body of evidence supporting the beneficial role of adipose-derived stem cells (ASCs) in tissue repair and regeneration. These effects appear to be mainly mediated by paracrine signaling pathways and enhanced during hypoxia. Mass spectrometry (MS) represents a valuable tool for prote...
ORGANISM(S): Homo sapiens (Human) 
2016-04-18 | PXD003550 | Pride
Proteomics Hypoxia Adipose-derived stem cells Serum-free culture Secretome 
ProteomicsData in support of Synthesis and deposition of basement membrane proteins by primary brain capillary endothelial cells in a murine model of the blood-brain barrier
The aim of the present study was to analyze four different in vitro models of the murine BBB for expression and possible secretion of major basement membrane proteins from murine BCECs (mBCECs). The mBCECs and pericytes were isolated from brains of adult C57BL/6 mice, and glial cells (mainly astrocy...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-03 | PXD003981 | Pride
Blood-brain barrier  primary murine capillary endothelial cells  basement membrane  in vitro models 
ProteomicsProteomic and unbiased post-translational modification profiling of amyloid plaques and surrounding tissue in a transgenic mouse model of Alzheimer’s disease
Amyloid plaques (Aβ plaques) are one of the hallmarks of Alzheimer’s disease (AD). The main constituent of Aβ plaques is beta-amyloid peptides but a complex interplay of other infiltrating proteins also co-localizes. We focused on proteomic differences between Aβ plaques and adjacent control tissue ...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-25 | PXD014274 | Pride
Amyloid plaque Alzheimer’s disease Mass spectrometry Post transcriptional modifications Laser capture microdissection 
ProteomicsData in support of administration of a soluble TNF inhibitor that reduces infarct volume after focal cerebral ischemia in mice
Background: Tumor necrosis factor, which exists both as a soluble (solTNF) and a transmembrane (tmTNF) protein, plays an important role in post-stroke inflammation. The objective of the present study was to test the effect of topical versus intracerebroventricular administration of XPro1595 (a solTN...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD014440 | Pride
Microglial activation Cytokines Neuroprotection Ischemic stroke Behavior 
ProteomicsDataset in support of patients on clinical suspicion of infective endocarditis included in a study searching for novel putative biomarkers
Infective endocarditis (IE) has high mortality, partly due to delayed diagnosis and treatment. Currently, no biomarker can identify IE in patients with fever and clinical picture of infection. To find putative biomarkers we analyzed serum levels of two proteins found in cardiac valves, osteoproteger...
ORGANISM(S): Homo sapiens (Human) 
2020-02-26 | PXD010149 | Pride
Biomarkers  infective endocarditis  lfq lc-ms/ms  non-infective endocarditis  serum proteomics  2d-page 
ProteomicsData in support of serum proteomics of Laparoscopic Gastric Plication
Laparoscopic Gastric Plication (LGP) is a relatively new bariatric surgery procedure unique by not removing any part of the stomach. To bring new insights into the underlying molecular mechanism, we here present the first hypothesis-free analysis of the impact of LGP on the inflammatory and metaboli...
ORGANISM(S): Homo sapiens (Human) 
2019-06-06 | PXD010528 | Pride
Serum laparoscopic gastric plication 
ProteomicsProteome analysis of adipose-derived stem cells cultured under clinically relevant conditions in a wound healing perspective
There is a large body of evidence supporting the beneficial role of adipose-derived stem cells (ASCs) in tissue repair and regeneration. These effects appear to be mainly mediated by paracrine signaling pathways and enhanced during hypoxia. Mass spectrometry (MS) represents a valuable tool for prote...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080858 | MassIVE
ProteomicsData in support of proteomics of EVs ámd mimetic vesicles from
Exosomes (EXOs) are a biological subset of extracellular vesicles of 50-200 nm in size which are released by most cells upon fusion of multivehicular bodies with plasma membrane.Mimetic-Nanovesicles (M-NVs) have higher yield compare to exosomes. In addition, M-NVs can untangle the difficulties assoc...
ORGANISM(S): Homo sapiens (Human) 
2022-01-05 | PXD010539 | Pride
Microvesicles proteomics 
Sort   by:  
 Page size