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ProteomicsNCAM1: A Novel Autoantigen in Membranous Lupus Nephritis
Membranous lupus nephritis is a frequent cause of nephrotic syndrome in patients with systemic lupus erythematosus. Unlike phospholipase A2 receptor or thrombospondin type 1 domain containing 7A-associated membranous nephropathy, where known antibodies can be detected within sera by indirect immun...
ORGANISM(S): Homo sapiens (Human) 
2020-10-19 | PXD021123 | Pride
Human Kidney Dda 
ProteomicsCubilin is a Novel Target Antigen in Anti-Brush Border Antibody Disease
Autoimmune diseases that affect the kidney proximal tubule (PT) cause proteinuria and are implicated in the pathogenesis of kidney failure. Previous evidence demonstrated that circulating anti-brush border antibodies (ABBA) target megalin (LRP2) but whether other components of the PT drive autoimmun...
ORGANISM(S): Homo sapiens (Human) 
2023-04-06 | PXD030159 | Pride
Human Dia Kidney Lc-ms 
ProteomicsProteomic analysis of the Ade6-M26 meiotic recombination hotspot in the fission yeast schizosaccharomyces pombe
Homologous recombination events during meiosis cluster at specific loci called hotspots. Hotspot activation requires accessible chromatin, DNA sequence motifs DNA sequence-specific binding proteins, but how these proteins create a suitable environment for Rec12 recruitment is unknown. Here, we pur...
ORGANISM(S): Schizosaccharomyces pombe 
2018-11-04 | PXD009649 | Pride
Meiotic recombination hotspot m26 affinity purification 
ProteomicsTransforming growth factor receptor beta 3 (TGFBR3)-associated membranous nephropathy
We utilized mass spectrometry for protein discovery through enrichment of glomerular proteins by laser capture microdissection and through elution of immune complexes within MLN biopsies.
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD026506 | Pride
Pulldown Lcmd Lcms Kidney 
ProteomicsDNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells
To gain insight into the function of DNA-PKcs within immune cells, we performed a quantitative phosphoproteomic screen in T cells to identify first order phosphorylation targets of DNA-PKcs. Results indicate that DNA-PKcs phosphorylates the transcription factor Egr1 (early growth response protein 1)...
ORGANISM(S): Homo sapiens (Human) 
2021-12-21 | PXD026352 | Pride
Ms3 Phospo Tmt 
ProteomicsQuantitative proteomic analysis of heat shock response using tandem mass tags
Analysis of precision of TMT quantitation at the peptide level using multinotch MS3
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-02-17 | PXD014552 | Pride
Lc-ms Tmt 
ProteomicsQuantitative proteomic analysis of heat shock response using tandem mass tags
Analysis of precision of TMT quantitation at the peptide level using multinotch MS3
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-02-18 | PXD012973 | Pride
Lc-ms Tmt 
ProteomicsMinor Antigens in Membranous Nephropathy Identified by Mass Spectrometry
Background: Multiple autoantigens have been identified in membranous nephropathy (MN) by tissue-based proteomics. However, the antigenic targets of disease are unknown for >10% of MN and >50% of membranous lupus nephritis (MLN) cases. We identified multiple new targets in PLA2R-/THSD7A-/EXT-/NELL1-q...
ORGANISM(S): Homo sapiens (Human) 
2023-04-06 | PXD035854 | Pride
Human Kidney Pulldown Membranous nephropathy Dda 
ProteomicsMinor Antigens in Membranous Nephropathy Identified by Mass Spectrometry
Background: Multiple autoantigens have been identified in membranous nephropathy (MN) by tissue-based proteomics. However, the antigenic targets of disease are unknown for >10% of MN and >50% of membranous lupus nephritis (MLN) cases. We identified multiple new targets in PLA2R-/THSD7A-/EXT-/NELL1-q...
ORGANISM(S): Homo sapiens (Human) 
2023-04-06 | PXD035853 | Pride
Human Dia Kidney Pulldown Membranous nephropathy Dda 
MetabolomicsProtein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite interactions that mediate these networks are frequently low affinity and challenging to systematically discover. We developed mass spectrometry integrated with equilibrium dialysis for the disco...

2023-08-07 | MTBLS7237 | MetaboLights
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