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ProteomicsProteome profiling of extracellular vesicles from neurosurgical aspirates identifies CCT6A as a potential glioblastoma biomarker with prognostic significance
Glioblastoma, WHO-grade IV glioma, carries a dismal prognosis owing to its infiltrative growth rates and limited treatment options. Glioblastoma-derived extracellular vesicles (EVs; 30-1000nm membranous particles) influence the microenvironment to mediate tumour aggressiveness and carry oncogenic ca...
ORGANISM(S): Homo sapiens (Human) 
2022-03-01 | PXD010247 | Pride
Human Tumour Brain Extracellular vesicles Cct6a Glioblastoma Biomarker Glioma Exosomes Lc-ms/ms 
ProteomicsTime-resolved proteomic profiling for CHO-K1 fed-batch cultivations
The majority of recombinant protein therapeutics are produced with Chinese Hamster Ovary (CHO) cells. Productivity depends on the initial cell line engineering in terms of integration site or choice of an appropriate promotor for the recombinant gene expression, as well as media and process paramete...
ORGANISM(S): Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2021-01-25 | PXD018439 | Pride
Fedbatch cultivation Nlc-ms/ms Cho Proteomics Dda 
ProteomicsHEK293 femtomolar GPCR signaling
G protein-coupled receptors (GPCRs) are the largest class of cell surface signaling proteins; they participate in all physiological processes and are the targets of 30% of marketed drugs. Typically, nanomolar-micromolar concentrations of ligand are used to activate GPCRs in experimental systems. How...
ORGANISM(S): Homo sapiens (Human) 
2018-10-11 | PXD011033 | Pride
Compartmentalized signaling Femtomolar Camp B2ar M3r Signaling complex Gpcr Highly sensitive Ultra-low 
UnknownMetformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol.
Not available
S-EPMC12303861 | biostudies-literature
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